In microdosimetry, lineal energies y are calculated from energy depositions ? inside the microdosimeter divided by mean chord length , whose value is based on geometrical assumptions both detector and radiation field. This work presents an innovative two-stages hybrid (HDM: for microdosimetry) composed a tissue equivalent proportional counter silicon tracker made of 4 low gain avalanche diode. ...

An ion transport code was developed for simulating ionization energy deposition by energetic ions in sensitive volumes of complex structures. The code was used to simulate recent microdosimetry measurements performed with silicon-on-insulator (SOI) microdosimeters in Fast Neutron Therapy (FNT).

Bystander or non-targeted effect is known to be an interesting phenomenon in radiobiology. The genetic consequences of bystander effect on non-irradiated cells have shown that this phenomenon can be considered as one of the most important factors involved in secondary cancer after exposure to ionizing radiation. Every year, millions of people around the world undergo radiotherapy in order to cu...

Enhancing the effect of radiation on tumors would be a significant improvement in radiation therapy. With radiation enhancement, less radiation could be used to achieve the same goals, lessening damage to healthy tissue and lessening side effects. Gold nanoparticles are a promising method for achieving this enhancement, particularly when the gold nanoparticles are targeted to cancer. This liter...

Introduction: In the present study, AS1411 aptamer conjugated gold nanoclusters (GNCs) have been introduced as a targeted radiosensitizer for enhancing megavoltage radiation therapy efficacy. RT has identified as an effective therapeutic modality for many different types of solid tumors. However, equal radiation beams absorption by tumor and surrounding healthy tissues is still...