In the attempt to elucidate if the "peripheral sink hypothesis" could be a potential mechanism of action for tau removal in passive immunotherapy experiments, we have examined tau levels in serum of chronically injected JNPL3 and Tg4510 transgenic animals. Measurement of tau in serum of mice treated with tau antibodies is challenging because of the antibody interference in sandwich enzyme-linke...

BACKGROUND The time constant of isovolumic relaxation (tau) is an important parameter of ventricular diastolic function, but the need for invasive measurement with high-fidelity catheters has limited its use in general clinical cardiology. The Doppler mitral regurgitant velocity spectrum can be used to estimate left ventricular (LV) pressure throughout systole and may provide a new noninvasive ...

‎It is shown that the knowledge of a surjective morphism $Xto Y$ of complex‎ ‎curves can be effectively used‎ ‎to make explicit calculations‎. ‎The method is demonstrated‎ ‎by the calculation of $j(ntau)$ (for some small $n$) in terms of $j(tau)$ for the elliptic curve ‎with period lattice $(1,tau)$‎, ‎the period matrix for the Jacobian of a family of genus-$2$ curves‎ ‎complementing the classi...

‎let $r$ be a $*$-prime ring with center‎ ‎$z(r)$‎, ‎$d$ a non-zero $(sigma,tau)$-derivation of $r$ with associated‎ ‎automorphisms $sigma$ and $tau$ of $r$‎, ‎such that $sigma$‎, ‎$tau$‎ ‎and $d$ commute with $'*'$‎. ‎suppose that $u$ is an ideal of $r$ such that $u^*=u$‎, ‎and $c_{sigma,tau}={cin‎ ‎r~|~csigma(x)=tau(x)c~mbox{for~all}~xin r}.$ in the present paper‎, ‎it is shown that...

We present a simple method for directly measuring the average dwell time of spin-polarized Rb atoms on coated Pyrex glass surfaces. The method relies on the light shift of the Zeeman resonances of spin-polarized Rb atoms pumped and probed by evanescent waves, and does not depend on the microscopic details of surface interactions. We use a cell whose length is adjustable between 70 and 500 micro...

objective(s):alzheimer's disease (ad) is the most common age-related neurodegenerative disorder. one of the hallmarks of ad is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. in this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in ad and tauopathies. unfortunately, the available syn...

tau is one of several types of microtubule-associated proteins (maps), responsible for the assembly and stability of microtubule networks that is present only in neurons and predominantly localized in axons which its functions are tightly regulated by phosphorylation. via as yet unknown mechanisms, tau becomes hyperphosphorylated and accompanies with neuronal degeneration, loss of synapses, abe...

Poor axial precision caused, in part, by large depth of focus (tau) has been a vexing problem in extraction of particle position from digital in-line holograms. A simple method is proposed to combat this depth-of-focus difficulty. The method is based on decoupling of size and position information. With d, Delta, and lambda being particle diameter, CCD pixel size, and the wavelength, respectivel...

We aim to construct higher order tau-leaping methods for numerically simulating stochastic chemical kinetic systems in this paper. By adding a random correction to the primitive tau-leaping scheme in each time step, we greatly improve the accuracy of the tau-leaping approximations. This gain in accuracy actually comes from the reduction in the local truncation error of the scheme in the order o...

BACKGROUND Quantitative in vivo imaging of tau pathologies potentially improves diagnostic accuracy of neurodegenerative tauopathies and would facilitate evaluation of disease-modifying drugs targeting tau lesions in these diseases. Tau pathology can be quantified by reference tissue models without arterial blood sampling when reference tissue devoid of target binding sites is available. The ce...