The clostridial neurotoxin (CNT) family includes botulinum neurotoxin (BoNT), serotypes A, B, E, and F of which can cause human botulism, and tetanus neurotoxin (TeNT), which is the causative agent of tetanus. This suggests that the greatest need is for a multivalent or multiagent vaccine that provides protection against all 5 agents. In this study, we investigated the feasibility of generating...

Tetanus (TeNT) is a zinc protease that blocks neurotransmission by cleaving the synaptic protein vesicle-associated membrane protein/synaptobrevin. Although its intracellular catalytic activity is well established, the mechanism by which this neurotoxin interacts with the neuronal surface is not known. In this study, we characterize p15s, the first plasma membrane TeNT binding proteins and we s...

Tetanus neurotoxin (TeNT) and botulinum neurotoxins (BoNTs; from A to G) are metalloproteases that act on nerve terminals to prevent exocytosis. They are extensively exploited for the study of cellular physiology. Moreover, BoNTs are also employed in clinical neurology for the treatment of several disorders characterized by hyperexcitability of peripheral nerve terminals. This review summarizes...

This paper describes recent development e orts on the integrated simulation environment TENT. TENT is a component-based software integration and work ow management system using the capabilities of CORBA and Java. It is used to integrate the applications required to form complex work ows, which are typical of multidisciplinary simulations in engineering, in which di erent simulation codes have t...

SUMMARY This paper describes recent development eeorts on the integrated simulation environment TENT. TENT is a component-based software integration and workkow management system using the capabilities of CORBA and Java. It is used to integrate the applications required to form complex workkows, which are typical of multidisciplinary simulations in engineering, in which diierent simulation code...

the functions of shelters are basically the same everywhere: to avoid extreme weather and to provide shelter for a comfortable living and working environment; but the designs and processes for those in different climates are significantly different. to live in the tropical area, olgyay stated two major problems the habitants have to be prepared for: the avoidance of excessive solar radiation an...

We consider a family of chaotic skew tent maps. The skew tent map is a two-parameter, piecewise-linear, weakly-unimodal, map of the interval Fa;b. We show that Fa;b is Markov for a dense set of parameters in the chaotic region, and we exactly nd the probability density function (pdf), for any of these maps. It is well known, [1], that when a sequence of transformations has a uniform limit F , a...