Until recently it was believed that atherosclerotic lesions of the aorta induced by hypercholesterolemia always faithfully reflected changes in other arteries. Thus intensive experimental analysis of factors reducing hypercholesterolemia and protecting the aorta against atherosclerosis were undertaken in the belief that such factors would also protect the coronary and other arteries against ath...

The presence in serum of a powerful inhibitor of trypsin and certain other proteolytic enzymes has been known for a long time. Considerable at tention has been given to its activity in disease, particularly cancer. It appears that, in the major ity of cases of early malignancy, the inhibitor is elevated (9), diminishing again in advanced stages (6). Neither in cancer, however, nor in other dise...

Task pools have many important applications in distributed and parallel computing. Pools are typ-ically implemented using concurrent queues, which limits their scalability. We introduce CAFÉ, Con-tention and Fairness Explorer, a scalable and wait-free task pool which allows users to control thetrade-off between fairness and contention. The main idea behind CAFÉ is to maintain a list...

agents has received considerable experimental at tention during the last few years, and a variety of mechanisms of action have been postulated to ac count for the effect. Much of this investigation has centered on the interaction of these agents with deoxyribonucleic acid (DNA) (1, 3, 4, 9, 11, 13, 19—9292)following the initial suggestion by Elmore et at. (8) that sulfur mustard probably atta...

In a study of myelin formation in thin sections of mouse optic nerve, several node-like discontinuities in the myelin sheath have been observed. Since previously published electron micrographs of such discontinuities in nerve fibers of the rat central nervous system (1, 2) lacked sufficient detail to resolve the glial cytoplasm--myelin lamellar relationships, it appears worthwhile to present th...

Four experiments examined the roles of melodic contour and pitch in­ terval information in recognition memory for melodies. In Experi­ ments I and 2, subjects heard excerpts from Beethoven String Quartets, and subsequently attempted to detect copies of input melodies (Targets) as well as Related items, which resembled input items with respect to contour and rhythm, but not pitch intervals. Targ...

BACKGROUND Bedtime administration of antihypertensive drugs currently receives more at-tention, but no clear consensus has been reached on the blood pressure (BP)-lowering effect of this strategy. METHODS We systematically searched literature for clinical trials of ingestion time of anti-hypertensive drugs evaluated by ambulatory blood pressure monitoring (ABPM) to perform a meta-analysis whi...

Background: Clinical skills training related to personal hygiene causes anxiety and stress among nursing students due to the fact that they use each other as “patients”. To justify this learning activity more knowledge about the students’ experiences and learning outcome is needed. Aim: To describe how nursing students experience clinical skills training using one another as “patient”. Method: ...

The toxicity and antitumor activity of liposomal vincristine prepara tions have been examined. Vincristine was encapsulated inside egg phosphatidylcholine (EPC)/cholesterol (55/45, mol/mol) and distearoylphosphatidylcholine (DSPC)/cholesterol (55/45, mol/mol) vesicles utilizing transmembrane pH gradient (inside acidic) drug uptake processes. Trap ping efficiencies approaching 100% were achieved...

BACKGROUND Previous reviews of the effectiveness of antibiotic prophylaxis for elective inguinal hernia repair were not conclusive owing to the limited number of patients enrolled in randomized controlled trials (RCTs). However, since new RCTs involving patients undergoing tention-free hernioplasty have been published in recent years, we performed a new meta-analysis to evaluate the effectivene...