Chronic toxicity, rat: No data gap, no adverse effect Chronic toxicity, dog: No data gap, no adverse effect Oncogenicity, rat: No data gap, no adverse effect Oncogenicity, mouse: No data gap, no adverse effect Reproduction, rat: No data gap, no adverse effect Teratology, rat: No data gap, no adverse effect Teratology, rabbit: No data gap, no adverse effect Gene mutation: No data gap, no adverse...

Chronic toxicity, rat: No data gap, no adverse effect indicated. Chronic toxicity, dog: No data gap, no adverse effect indicated. Oncogenicity, rat: No data gap, no adverse effect indicated. Oncogenicity, mouse: No data gap, no adverse effect indicated. Reproduction, rat: No data gap, no adverse effect indicated. Teratology, rat: No data gap, no adverse effect indicated. Teratology, rabbit: No ...

Autism spectrum disorders affect behaviors that emerge at ages when typically developing children become increasingly social and communicative, but many lines of evidence suggest that the underlying alterations in the brain occur long before the period when symptoms become obvious. Studies of the behavior of children in the first year of life demonstrate that symptoms are often detectable in th...

A mixed model framework is presented to model the characteristic multivariate binary anomaly data as provided in some teratology studies. The key features of the model are the incorporation of covariate effects, a flexible random effects distribution by means of a finite mixture, and the application of copula functions to better account for the relation structure of the anomalies. The framework...

Isidore Geoffroy Saint-Hilaire studied anatomy and congenital abnormalities in humans [2] and other animals in nineteenth century France. Under the tutelage of his father, Étienne Geoffroy Saint-Hilaire, Isidore compiled and built on his father's studies of individuals with developmental malformations, then called monstrosities. In 1832, Isidore published Histoire générale et particulière des a...

Chronic toxicity, rat: No data gap, possible adverse effect Chronic toxicity, dog: No data gap, no adverse effect indicated Oncogenicity, rat: No data gap, no adverse effect indicated Oncogenicity, mouse: No data gap, no adverse effect indicated Reproduction, rat: No data gap, no adverse effect indicated Teratology, rat: No data gap, no adverse effect indicated Teratology, rabbit: No data gap, ...

Given this inherent complexity, the text is remarkably well integrated and presents a balanced picture of current knowledge and questions. As in any book written by many authors, the style and quality of chapters vary, but the overall quality of writing is very good. The chapters by Milton Hildebrand ("Walking and Running"), James L. Edwards ("Terrestrial Locomotion Without Appendages"), and Jo...

Due to the scope of the discipline, an annual survey of teratology must encompass a broad spectrum of findings from the bio-medical sciences. The first volume in this series does range topically in including reviews on aspects of cytogenetic, pharmacological, radiobiological, and immunological problems. If a field such as teratology is to be reviewed, one cannot expect a high degree of correspo...