introduction: to examine the effects of opium dependence and cigarette smoking on semen quality and sperm parameters, the semen quality of men who abuse opiates and/or smoke cigarettes was investigated in a retrospective study. methods: male partners of 1325 infertile couples attending the infertility clinic for intrauterine insemination (iui) procedure were divided into non-smoking non-opium (...

Introduction: To examine the effects of opium dependence and cigarette smoking on semen quality and sperm parameters, the semen quality of men who abuse opiates and/or smoke cigarettes was investigated in a retrospective study. Methods: Male partners of 1325 infertile couples attending the infertility clinic for intrauterine insemination (IUI) procedure were divided into non-smoking non-op...

Abstract Background: Single nucleotide polymorphisms (SNPs) in some genes which are involving in sperm maturation, are considered as one of the main reason for male infertility. Any changes in protamine genes may cause abnormal histone-protamine replacement during spermiogenesis and have been indicated to cause sperm DNA damage and infertility. Objective: The aim of present case-control study w...

The objective of this study was to assess fertilization, implantation and pregnancy rates in infertile patients with severe teratozoospermia [P (poor prognosis) pattern sperm morphology assessed by strict criteria] treated by in-vitro fertilization (IVF) using a high insemination concentration (HIC), or by intracytoplasmic sperm injection (ICSI). This was a retrospective cohort study performed ...

ING2 (inhibitor of growth family, member 2) is a member of the plant homeodomain (PHD)-containing ING family of putative tumor suppressors. As part of mSin3A-HDAC corepressor complexes, ING2 binds to tri-methylated lysine 4 of histone H3 (H3K4me3) to regulate chromatin modification and gene expression. ING2 also functionally interacts with the tumor suppressor protein p53 to regulate cellular s...

The androgen receptor (AR) is a protein encoded by the AR gene, which when mutated may affect spermatogenesis, the process in which spermatozoa are produced; thus, AR mutations could lead to male infertility. We examined exon 1 of the AR gene in men with idiopathic infertility. Blood or semen samples from 111 infertile, oligozoospermic (N = 31), asthenozoospermic (N = 23), teratozoospermic (N =...

Abstract Study question Does advancing male age influence the frequency of occurrence sperm abnormalities? Summary answer Advancing was associated with increased incidence certain head and tail defects – elongated head, nuclear vacuoles, coiled tail. What is known already Evaluation reproductive potential based mainly on motility morphology. Morphological features serve as a reliable indicator ...

The present study determined an association between idiopathic sperm disorders in a local Pakistani infertile male population and the MTHFR C677T polymorphism. After ruling out non genetic factors, a total of 437 idiopathic infertile men including 57 azoospermic, 66 oligospermic, 44 asthenozoospermic, 29 teratozoospermic, 20 oligoasthenospermic and 221 infertile normospermic men were recruited....

BACKGROUND Glycosidases profusion in male reproductive fluids suggests a possible relationship with sperm function. Although Hexosaminidase (Hex) is the most active glycosidase in epididymal fluid and seminal plasma, as well as in spermatozoa, Glucosidase is considered a marker for epididymal function and azoospermia. OBJECTIVE The aim of this study was to determine Hex activity in seminal pl...