BACKGROUND Measurement of amino-terminal pro-B-type natriuretic peptide (NT-proBNP) is useful for evaluating patients with heart failure (HF). METHODS We evaluated the performance of a new automated NT-proBNP assay. RESULTS The VITROS NT-proBNP assay had mean within-run and total imprecision of 1.0% and 3.4% at NT-proBNP concentrations from 67-27,500 ng/l. Acceptable linearity, functional/a...

BNP or NT-proBNP testing has dramatically changed the management of acute heart failure patients by aiding in early recognition, prognostication and treatment. Furthermore, recent studies have shown that natriuretic peptide testing may guide the therapy of the stable chronic heart failure patients in out-patient setting. We will review the understanding of utilizing natriuretic peptide testing ...

The B-type natriuretic peptides; B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide, are increasing being used as biomarkers for the diagnosis, management and prognostication of cardiac failure, but their application in the peri-operative period is unclear. This review examines the current understanding of the role of B-type natriuretic peptides in both the operative and n...

The introduction of novel biomarkers necessitates their detailed study in patients with different heart failure (HF) phenotypes as part a personalized approach to assessing the disease severity and predicting outcomes. Aim . To assessthe activity following neurohormonal systems: N-terminal probrain natriuretic peptide (NT-proBNP) galectin-3 HF preserved, mildly reduced ejection fraction (EF). M...

OBJECTIVE To correlate the serum levels of B type natriuretic peptide and the N-terminal fraction of the pro-B type natriuretic peptide, as well as to analyze the influence of age, obesity, renal failure, left ventricle ejection fraction, diastolic dysfunction, and anemia on serum levels of both markers. METHODS An observational study in which the agreement was compared between these markers ...

circulating levels of natriuretic peptides predict future cardiac event in patients with chronic hemodialysis. Nephron 2002;92:610–5. 14. Naganuma T, Sugimura K, Wada S, Yasumoto R, Sugimura T, Masuda C, et al. The prognostic role of brain natriuretic peptides in hemodialysis patients. Am J Nephrol 2002;22:437–44. 15. Parfrey PS. Cardiac disease in dialysis patients: diagnosis, burden of diseas...

Measurement of circulating B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) can identify patients with heart failure and guide therapy. The limit of detection, linearity, imprecision, method comparison, analytic concordance, and reference intervals of the Access 2 BNP (Biosite, San Diego, CA), ADVIA Centaur BNP (Bayer Diagnostics, Tarrytown, NY), AxSYM BNP (Abbott Diagnostics,...

Toward personalized risk assessment in patients with chronic heart failure: Detailed temporal patterns of NT-proBNP, troponin T, and CRP in the Bio-SHiFT study Nick van Boven, MD, a,b,1 Linda C. Battes, MD, PhD, b,1 K. Martijn Akkerhuis, MD, PhD, b Dimitris Rizopoulos, PhD, c Kadir Caliskan, MD, PhD, b Sharda S. Anroedh, MD, b Wisam Yassi, MD, a Olivier C. Manintveld, MD, PhD, b Jan-Hein Cornel...

Endopeptidase-24.11 (E-24. 11, EC 3.4.24.11) is widely believed to play a physiological role in metabolizing atrial natriuretic peptide (ANP). Since the discovery of ANP, new natriuretic peptides have been isolated and other peptides synthesized as receptor ligands. The hydrolysis in vitro of six related peptides by the endopeptidase has been studied, mainly by h.p.l.c. The initial attack on th...