• draw the mechanism of ester hydrolysis under acidic and basic reaction conditions; • account for the irreversibility of the hydrolysis reaction under basic conditions; • form new esters by baseor acid-catalysed transesterification mechanisms; • draw the mechanism for cleaving tert-butyl esters and understand why the mechanism is different from that for methyl esters; • understand why protonat...

The asymmetric synthesis of the orthogonally funtionalised compounds tert-butyl 2-N-benzyl-N-alpha-methylbenzylamino-5-methoxycarbonylmethylcyclopentane- 1-carboxylate and methyl 2-N-benzyl-N-alpha-methylbenzylamino-5-carboxymethylcyclo- pentane-1-carboxylate by a domino reaction of tert-butyl methyl (E,E)-octa-2,6- diendioate with lithium N-alpha-methylbenzyl-N-benzylamide initiated by a Micha...

Ruthenium-catalyzed butadiene-mediated benzannulation enabled the first synthesis of 3,10-(di-tert-butyl)rubicene and its N-doped derivatives as well preliminary studies on their photophysical properties. Unlike parent rubicene 3,10-(di-tert-butyl)rubicene, which adopt classical herringbone-type packing motifs in solid state, congener 7 b displayed columnar with an alternating co-facial arrange...

We have synthesized a novel chiral NADH model compound, N-methyl-(R)-3-(tert-butyl)-sulphinyl-1,4-dihydropyridine with high enantioselectivity and used it in the reduction of methyl benzoylformate, producing (S)-methyl mandelate in 95% ee. The absolute structure of its precursor, 3-(tert-butyl)sulfinyl pyridine, was determined by X-ray analysis.

A convenient and practical synthesis of imidazol-1-yl-acetic acid hydrochloride was achieved via N-alkylation of imidazole using tert-butyl chloroacetate followed by a non-aqueous ester cleavage of the resulting imidazol-1-yl-acetic acid tert-butyl ester in the presence of titanium tetrachloride. The synthesized imidazol-1-yl-acetic acid hydrochloride was then utilized to prepare zoledronic acid.

Background: Tert-butyl mercaptan is one of the frequently used odorants derived from natural gases. It has been declared as a health hazard by the Occupational Safety and Health Administration (OSHA) in the USA. There is not much information available about the mercaptans long-term toxicity secondary to occupational exposure. This study was conducted to evaluate the oxidative stress caused by m...

In the title compound, C(16)H(25)NO, the N-tert-butyl-propanamide fragment is essentially planar, with the exception of two C atoms of the tert-butyl group (r.m.s. deviation = 0.005 Å), forming a dihedral angle of 84.09 (10)° with the plane of the mesityl fragment (r.m.s. deviation = 0.002 Å). The crystal packing is stabilized by an inter-molecular N-H⋯O hydrogen bond, which links the mol-ecule...

A series of binuclear boron compounds supported by Salan(Bu)H4 ligands have been prepared. They are of the general formula Salan(Bu)[B(OR)]2. The compounds are Salean( Bu)(BOR)2 [Salean( Bu) = (N,N 0-ethylenebis(3,5-di-tert-butyl-salicylamine)), R = Me (1), SiMe3 (4)], Salban( Bu)(BOR)2[Salban( Bu) = (N,N 0-butylenebis(3,5-di-tert-butyl-salicylamine)), R = Me (2), SiMe3 (5)], and Salhan(Bu)(BOR...

The X-ray structure of the title compound was determined for first time. There are four independent molecules that form a repeat unit packed in crystal alternating pairs with orthogonal orientation and further joined into infinite chains by hydrogen bonding.