The tertiary phosphine oxides (TPO) comprise a large group of organophosphorus compounds to which a considerable attention in the literature is paid [1-5]. However, only few TPO ’s containing one or more primary amino groups in their mole­ cules are known. Studies on such compounds are limited [6-12]. Because of the high activity of amino groups these compounds can be used as phosphorylation ag...

A three-component cascade reaction of salicylaldehyde, malononitrile/cyanoacetate and nitromethane catalysed by chiral tertiary amino-thioureas was developed, which leads to the production of highly functionalized 2-amino-4H-chromenes in good yields with good to excellent enantioselectivities.

Although there is an abundance of evidence in support of the template hypothesis of protein biosynthesis (I), there appears to have been no satisfactory experimental basis for deciding whether the role of the template includes the coiling and folding of the protein chain to produce the secondary and tertiary structures’ or is restricted to the formation of amino acid sequence. It has been repor...

Proteins are polypeptide chains obtained by translation from strands of messenger RNA. The functional properties of proteins depend on their three-dimensional structures. The three-dimensional structure arises because particular sequences of amino acids in polypeptide chains fold to generate, from linear chains, compact domains with specific three-dimensional structures(Figure 19.1). Totally th...

Correlations between protein structures and amino acid sequences are widely used for protein structure prediction. For example, secondary structure predictors generally use correlations between a secondary structure sequence and corresponding primary structure sequence, whereas threading algorithms and similar tertiary structure predictors typically incorporate interresidue contact potentials. ...