Tetracyclines are a group of common antibiotics, but owing to their toxicity, most them only used in animal husbandry and veterinary medicine. A DNA aptamer for tetracyclines has recently been reported. Upon binding, the fluorescence was enhanced. This unique enhancement selectively detect tetracyclines. The purpose this study use graphene oxide (GO) suppress background enhanced detection. Firs...

In recent years, tetracyclines, such as doxycycline, have become broadly used to control gene expression by virtue of the Tet-on/Tet-off systems. However, the wide range of direct effects of tetracycline use has not been fully appreciated. We show here that these antibiotics induce a mitonuclear protein imbalance through their effects on mitochondrial translation, an effect that likely reflects...

This review addresses the role of adjunctive tetracycline therapy in the management of periodontal diseases and its efficacy in reducing inflammatory burden, oxidative stress and its sequelae in patients with coexisting features of metabolic syndrome. Removal of the dimethylamine group at C4 of the tetracycline molecule reduces its antibiotic properties, enhancing its non-antimicrobial actions;...

The flavin-dependent monooxygenase TetX confers resistance to all clinically relevant tetracyclines, including the recently approved, broad-spectrum antibiotic tigecycline (Tygacil®) which is a critical last-ditch defense against multidrug-resistant pathogens. TetX represents the first resistance mechanism against tigecycline, which circumvents both the tet-gene encoded resistances, relying on ...

There must be something unique about a class of drugs (discovered and developed in the mid-1940s) where there are more than 130 ongoing clinical trials currently listed. Tetracyclines were developed as a result of the screening of soil samples for antibiotic organisms. The first of these compounds chlortetracycline was introduced in 1948. Soon after their development tetracyclines were found to...

Received July 10, 2006 Abstract Objectives: To briefly outline the development and reasons for the decline in the clinical use of tetracyclines, and to consider if the side-effects of doxycycline a contra-indication to its use. Data Sources: Literature search of MEDLINE from 1950 to 2005. Study Selection: Literature and data related to doxycycline, tetracycline and tooth discolouration. Data Ex...

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