نتایج جستجو برای: tgf β antagonist
تعداد نتایج: 249600 فیلتر نتایج به سال:
Human lung fibroblasts are a potential source of endothelin-1 (ET-1), a pro-fibrotic mediator. The present study explored possible muscarinic and β-adrenergic modulations of ET-1 expression in human lung fibroblasts. MRC-5 human lung fibroblasts were cultured. Expression of prepro-endothelin-1 (ppET-1) mRNA was determined by quantitative real time PCR. [(3)H]-Proline incorporation was determine...
Background: TGF-β isoforms play crucial roles in diverse cellular processes. Therefore, targeting and inhibiting TGF-β signaling pathway provides a potential therapeutic opportunity. TGF-β isoforms bind and bring the receptors (TβRII and TβRI) together to form a signaling complex in an ordered manner. Objectives: Herein, an antagonistic variant of TGF-β (AnTβ)...
background: cutaneous leishmaniasis is a neglected parasitic disease, which imposes massive human distress and financial costs to the endemic countries. better understanding of host immune response to the parasite leads to helpful strategies for disease control. interleukin (il)-10 and transforming growth factor (tgf)-β are important immune regulatory cytokines, which appear to develop non-heal...
Background: Successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. It has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. Transforming growth factor beta (TGF- β) exhibits potent immunoregulatory and anti-inflammatory properties which might prolong graft survival. Recent studies suggest a ...
AIMS Arsenic trioxide (ATO), an effective therapeutic agent for acute promyelocytic leukaemia, can cause sudden cardiac death due to long QT syndrome (LQTS). The present study was designed to determine whether ATO could induce cardiac fibrosis and explore whether cardiac fibroblasts (CFs) are involved in the development of LQTS by ATO. METHODS AND RESULTS ATO treatment of guinea pigs caused s...
Islet transplantation has proven to be a successful strategy to restore normoglycemia in patients with type 1 diabetes (T1D). However, the dearth of cadaveric islets available for transplantation hampers the widespread application of this treatment option. Although human embryonic stem cells and induced pluripotent stem cells are capable of generating insulin-producing cells in vitro when provi...
سیستمیک اسکلروزیس نوعی بیماری بافت پیوندی است که معمولا پوست و در موارد پیشرفته آن ریه، کلیه و قلب را نیز درگیر مینماید. اتیولوژی و پاتولوژی این بیماری ناشناخته است. یک عامل موثر از قبیل ویروس یا مواد شیمیایی برای افرادی که از نظر ژنتیکی مستعد ابتلا به سیستمیک اسکلروزیس باشند، می تواند سرآغاز ایجاد بیماری باشد. از مکانیسم های احتمالی درگیر در پاتولوژی این بیماری آسیب به رگ های خونی کوچک، رسوب ک...
چند قلوزایی یکی از مهمترین صفات اقتصادی در پرورش بز است، که علاوه بر تأثیر پذیری از ژن های کوچک اثر، تحت تأثیر ژن های با اثر بزرگ نیز می باشد. در دهه های اخیر مشخص شد که دو عضو متعلق به خانواده فاکتورهای رشد با منشأ اووسیتی به نامهایgdf9 وbmp15 برای رشد فولیکولی و تخمک ریزی ضروری هستند. هدف از پژوهش حاضر مطلعهی چند شکلی در جایگاههای ژنی gdf9 وbmp15 و ارتباط الگوهای ژنوتیپی شناسایی شده در...
Medial degeneration is a key feature of aneurysm disease and aortic dissection. In a murine aneurysm model we investigated the structural and functional characteristics of aortic wall degeneration in adult fibulin-4 deficient mice and the potential therapeutic role of the angiotensin (Ang) II type 1 (AT(1)) receptor antagonist losartan in preventing aortic media degeneration. Adult mice with 2-...
Considerable evidence has demonstrated that transforming growth factor β (TGF-β) plays a key role in hepatic fibrosis, the final common pathway for a variety of chronic liver diseases leading to liver insufficiency. Although a few studies have reported that blocking TGF-β with soluble receptors or siRNA can prevent the progression of hepatic fibrosis, as yet no evidence has been provided that T...
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