objective(s): th2 response is related to the aetiology of asthma, but the underlying mechanism is unclear. to address this point, the effect of nebulized inhalation of inactivated mycobacterium phlei on modulation of asthmatic  airway  inflammation was investigated. materials and methods: 24 male balb/c mice were randomly divided into three groups: control group (group a), asthma model group (g...

in traditional chinese medicine, arsenous compounds, including arsenic trioxide (ato), are often used to treat many diseases, which are safe and effective. recently, studies have indicated that th17– il-17 involved in the pathogenesis and development of asthma. the goal of this study was to investigate the effect and mechanism of ato on asthma, especially the th17– il-17 axis. we used oval bumi...

Helper T cells producing IL-17 (Th17) have high plasticity: restimulation of lymphocytes in an inflammatory environment can induce their transformation into with another phenotype, and a shift towards Th1 is the most common. The result this appearance expressing along classical markers Th17 key Th1-associated molecules. In its general form, population represented by CD4 + CD161 CCR6 CXCR3 IFNγ ...

Inflammation of the upper respiratory tract in patients with allergic rhinitis (AR) may contribute to lower airways’ inflammation. T-helper 17 (Th17) cells and related cytokines are also involved immunological mechanism AR along classical Th2 cells. It is hypothesized that upon pressure, inflammatory response lungs lead Th17-induced neutrophilic However, findings for interleukin-17 (IL-17) bidi...

background: recurrent miscarriage (rm) affects 2-5% of pregnant women. paternal lymphocyte immunotherapy is a common treatment for rm patients but the outcome has not been consistent. therefore, combined therapy with other immunosuppressive drugs such as 1 a, 25-dihydroxy-vitamin-d3 (vitamin d3) may improve the outcome. objectives: to investigate the effect of vitamin d3 on the balance of two e...

In several murine models of autoimmune arthritis, Th17 cells are the dominant initiators of inflammation. In human arthritis the majority of IL-17-secreting cells within the joint express a cytokine phenotype intermediate between Th17 and Th1. Here we show that Th17/1 cells from the joints of children with inflammatory arthritis express high levels of both Th17 and Th1 lineage-specific transcri...

objective: micrornas (mirna) are a class of non-coding rnas which play key roles in post-transcriptional gene regulation. previous studies indicate that mirnas are dysregulated in patients with multiple sclerosis (ms). th17 and regulatory t (treg) cells are two subsets of cd4+ t-cells which have critical functions in the onset and progression of ms. the current study seeks to distinguish fluctu...

background: lack of sufficient information on the mechanism of plasma exchange (pe) therapy in multiple sclerosis (ms), has limited this treatment to individual patients with severe relapses who have been refractory to other treatments. this is while pe is used very successfully as a first-line standard treatment in many other neuro-immune disorders. recent data suggest that treg/th17 counterba...

There is growing evidence that Th17/regulatory T (Treg) imbalance associated with the etiology of autoimmune diseases. Heligmosomoides polygyrus (Hp) a natural intestinal parasite mice and has been shown to activate Tregs in host suppress symptoms diseases models. To evaluate involvement Th17/Treg balance pathogenesis systemic sclerosis (SSc), we investigated effect Hp-activated on bleomycin-in...