نتایج جستجو برای: th22
تعداد نتایج: 272 فیلتر نتایج به سال:
OBJECTIVE Helper T (Th) cell responses are critical for the pathogenesis of Helicobacter pylori-induced gastritis. Th22 cells represent a newly discovered Th cell subset, but their relevance to H. pylori-induced gastritis is unknown. DESIGN Flow cytometry, real-time PCR and ELISA analyses were performed to examine cell, protein and transcript levels in gastric samples from patients and mice i...
Atopic dermatitis (AD) is associated with the effects of T helper type 2 (Th2) and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating molecular changes during AD; IL-17A's role, however, has yet to be defined. The report by Nakajima et al. (this issue) begins to define that role by demon...
Some individuals are resistant to HIV-1 infection despite repeated exposure to the virus, suggesting the presence of a complex antiviral response. Innate factors like IL-22 exert gut mucosal protection and polyfunctional T cells have been associated with low progression in HIV infection; therefore, we evaluated the frequencies of CD4+ and CD8+ T cell-secreting cytokines, including Tc22/Th22 cel...
Newly identified T helper cell 22 (Th22) is a subset of CD4+ T cells with specific properties apart from other known CD4+ T cell subsets. Th22 is obviously discrete from Th17 and Th1 subsets by production of interleukin (IL)-22 but not IL-17 or IFN-γ, and also with distinguished expression of aryl hydrocarbon receptor (AHR) as the key transcription factor. This T helper subset, by producing pro...
T cells are key players in immune-mediated rheumatoid arthritis (RA). We previously reported that interleukin (IL)-22+CD4+T helper (IL-22+ Th) cells and IL-22 critically control the pathogenesis of RA. Here we monitored circulating levels of different IL-22+ Th cell subsets and measured plasma levels of IL-22, IL-17, and interferon (IFN)-γ in 60 patients with active RA following 12-week combina...
BACKGROUND Immunological mechanisms are increasingly recognized in the progression of myelodysplastic syndrome (MDS). Early-stage MDS (E-MDS) is characterized by autoimmune-mediated myelosuppression whereas late-stage MDS (L-MDS) involves immune evasion, giving dysplastic cells growth potential to progress into acute myeloid leukemia. T-helper (Th) 22 is involved in the pathogenesis of inflamma...
There is increased production of plasmacytoid dendritic cells (pDCs) in the bone marrow (BM) of multiple myeloma (MM) patients and these favor Th22 cell differentiation. Here, we found that the frequency of interleukin (IL)-22+IL-17-IL-13+ T cells is significantly increased in peripheral blood (PB) and BM of stage III and relapsed/refractory MM patients compared with healthy donors and patients...
چکیده زمینه و هدف: مولتیپل اسکلروزیس(ms) یک بیماری خودایمن سیستم اعصاب مرکزی است. اگرچه سلول های متعددی مانند سلول های b ، cd8+ t، میکروگلیا/ماکروفاژ، دندریتیک، آستروسیت و ماست سل در پاتوژنز بیماری ms نقش دارند، ولی به نظر می رسد که سلول های خود واکنش گر t cd4+ اختصاصی میلین، نقش مهمتری در پاتوژنز این بیماری دارند. در این مقاله یافته های اخیر در مورد نقش زیرگروه های سلول های t در پاتوژنز بیماری...
T helper 22 (Th22) cell populations are a newly identified subset of CD4+ cells that primarily mediate biological effects on the epithelial barrier through interleukin (IL)-22. Although, new studies showed both Th22 and IL-22 closely associated with pathogenesis inflammatory, autoimmune allergic disease as well malignancies. In this review, we aim to describe development characteristics their r...
leukemia is a hematological tumor in which the malignant myeloid or lymphoid subsets play a pivotal role. newly identified t helper cell 22 (th22) is a subset of cd4(+) t cells with distinguished gene expression, function and specific properties apart from other known cd4(+) t cell subsets.th22 cells are characterized by production of a distinct profile of effector cytokines, including interleu...
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