Black tea is one of the most popular natural beverages, which is consumed by the majority of the world population. Tea consumption has been reported to inhibit to tumor formation in various experimental and epidemiological studies (Katiyar and Mukhtar, 1996). Tea ingredients inhibit N-nitrosomethyl benzylamine, diethylnitrosoamine and polycyclic aromatic hydrocarbon induced esophageal, lung and...

BACKGROUND A major portion of the catechins in green tea is not absorbed in the small intestine. Bacteria in the colon convert nonabsorbed catechins into simpler phenolic compounds, which may also be absorbed. During the production of black tea, most catechins are polymerized to complex molecules called thearubigins. Little is known about the microbial degradation of these complex polyphenols, ...

Fatty acid synthase (FAS) is a major lipogenic enzyme catalyzing the synthesis of long-chain saturated fatty acids. Most breast cancers require lipogenesis for growth. Here, we demonstrated the effects of theanaphthoquinone (TNQ), a member of the thearubigins generated by the oxidation of theaflavin (TF-1), on the expression of FAS in human breast cancer cells. TNQ was found to suppress the EGF...

Cardiovascular complications are a major cause of morbidity and mortality in patients with diabetes, obesity and the metabolic syndrome. Recently, there has been an increasing interest in tea as a protective agent against CVD. Here, we compared the modulatory effects of two different doses (50 and 100 mg/kg body weight given orally for 28 consecutive days) of black tea aqueous extract (BTE, ric...

The beverage tea, from the top leaves of the plant Camellia sinensis is one of the most widely used beverages in the world, second only to water. Black and green tea have mostly similar actions. The active components are polyphenols, mainly epigallocatechin gallate in green tea, and the tea leaf polyphenol oxidase mediated oxidation to oolong and black tea, yielding other polyphenols, theaflavi...

S ince the first description of its clinical activity against multiple myeloma and mantle cell lymphoma, the proteasome inhibitor bortezomib has become a standard of care for patients with these diseases in the relapsed/refractory setting. Modulation of proteasome function has also become an established approach to overcome chemoresistance and achieve chemosensitization in patients with relapse...

introduction: tea (camellia sinensis), is the most widely beverage after water across the world. the most important chemical composition in tea is phenolic compounds (catechins) that have antioxidant and anticarcinogenic properties and are benefited for cardiovascular disease. there are two major kinds of tea, black tea and green tea. green tea, is originated in china and dates back to several ...