ABSTRACT. The aim of present study was the uses a series α,β-unsaturated carbonyl compounds (chalcones), in synthesis pyridine, pyran, thiophene, thiazole, together with their heterocyclic synthesis. work has resulted variety 2,5-dihydropyridine, hydrazide-hydrazone, thiophene derivatives, coumarin, pyran and thiazolo[4,5-d]thiazole derivatives. antitumor activities newly synthesized products w...

The benzo[d]thiazole derivatives 4a–c were synthesized and used for the synthesis of thiophene 6a–f. They form arylhydrazone 8a–i which capable to pyridazine 9a–i 10a–i. latter compounds reacted with thioglycolic acid produce thiazole 12a–i 13a–i, respectively. 15a–c also produced from through their reactions elemental sulfur phenylisothiocyanate. Further heterocyclization 15a carried out deriv...

Background and objective: Six families of thiazole, thiazolidine, imidazole, tetrahydropyrimidine, oxazolidine and thiazepine are new and important heterocyclic antibacterial compounds. Aim of this study is evalution the antibacterial effect of thirty new thiazole, thiazolidine, imidazole, tetrahydropyrimidine, oxazolidine and thiazepine derivatives against Bacillus subtilis and salmonella ente...

Simple three-component reactions between dialkyl acetylenedicarboxylate, primary amines and isothiocyanates in the presence of catalytic amount of ZnO nanorods are investigated in water at room temperature which produced thiazole derivatives in good yields.

A series of novel thiazole derivatives (A, A1, A2) were synthesized starting from 1-(3-methoxy phenyl) ethanone and thiourea. The compound (A) was obtained by heating 1-(3-methoxy phenyl) ethanone with thiourea in iodine. Compound (A) on treatment with 4-nitrobenzaldehyde afforded (Z)-4-(3-methoxyphenyl)-N-(4-nitrobenzylidene) thiazole-2-amine (A1). Acylation of compound (A) with 4-nitrobenzoyl...

The solid-solid reactions of thiosemicarbazide with 4-formylantipyrine, 2-acetylpyrrole and camphor were performed to afford the thiosemicarbazones 1-3 which underwent hetero-cyclization with phenacyl bromide to furnish the corresponding thiazole derivatives 4-6. The yields of the reactions are quantitative in all cases and the products do not require further purification. A series of 5-arylazo...

The structure-directing role of a variety noncovalent interactions in the solid state pyrazolyl-thiazole derivatives has been analyzed energetically using DFT calculations and by means Hirshfeld surface analysis.

Thiazoles and thiazolyl-pyrazole derivatives have been efficiently synthesized under neat reaction conditions in excellent yields. Condensation of 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one (1), thiosemicarbazide (2) and various carbonyl compounds (3 & 5) gave corresponding thiazole (4) and thiazolylpyrazole derivatives (6) in excellent yields by using Hantzsch-Thiazole synthesis. The ...