Nonatherosclerotic areas in human arteries display an age-related accumulation of cholesteryl ester in the form of small, perifibrous lipid droplets in the deeper intimal layers. We treated human aortic specimens with an osmium-thiocarbohydrazide-osmium sequence en bloc after glutaraldehyde fixation in order to provide electron dense staining of neutral lipid for ultrastructural study. Neutral ...

A series of cyclic analogues of bioactive thiosemicarbazide derivatives have been synthesized as potential antimycobacterial agents. The 4-amino-1,2,4-triazole-5-thione analogues (Ia-f) were prepared by heating a mixture of thiocarbohydrzide and appropriate carboxylic acids. Reaction of thiocarbohydrazide with γ-ketoesters in the presence of sodium methoxide furnished triazolopyridazine derivat...

A series of cyclic analogues of bioactive thiosemicarbazide derivatives have been synthesized as potential antimycobacterial agents. The 4-amino-1,2,4-triazole-5-thione analogues (Ia-f) were prepared by heating a mixture of thiocarbohydrzide and appropriate carboxylic acids. Reaction of thiocarbohydrazide with γ-ketoesters in the presence of sodium methoxide furnished triazolopyridazine derivat...

In this work, we reported the synthesis and evaluation of antimycobacterial and antifungalactivity of a series of thiocarbohydrazone derivatives which are thiacetazone congeners. Thetarget compounds were synthesized in superior yields by reacting thiocarbohydrazide withdifferent aromatic aldehydes and methyl ketones. Compounds 8, 19 and 25 were found to bethe most potent derivatives, exhibiting...

In this work the pharmacological study and synthesis of new thiadiazine bearing on triazole which obtained from hippuric acid , indomethacin mefenamic that have carboxylic moiety, Drugs with groups thiocarbohydrazide interacted to produce 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol (1a-c).
 starting products 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol) were treated chloroacetyl chloride final (2...

Al though the in t roduct ion of fixation of tissue with osmium tetroxide by Palade (8) ushered in the modern era of electron microscopy of biological materials, a need for greater contrast and greater resolution in visualizing membranous structures has s t imulated the in t roduct ion of methods for staining with heavy metal salts, in order to enhance the del ineat ion of the fine archi tectur...

PURPOSE To demonstrate histochemically the cellular distribution of particulate glycogen in the cat retina and to correlate it with glucose sensitivity of neuronal electrical activities. METHODS Free-floating, ultrathin sections of cat eyes (without glucose challenges) were stained by the periodic acid-thiocarbohydrazide-silver proteinate procedure and examined by electron microscopy. RESUL...

in this work, we reported the synthesis and evaluation of antimycobacterial and antifungalactivity of a series of thiocarbohydrazone derivatives which are thiacetazone congeners. thetarget compounds were synthesized in superior yields by reacting thiocarbohydrazide withdifferent aromatic aldehydes and methyl ketones. compounds 8, 19 and 25 were found to bethe most potent derivatives, exhibiting...