A highly efficient one-pot three-component protocol was devised for the synthesis of novel derivatives ((phenylethlidene)hydrazinyl)thiazol-4(5H)one by reaction acetophenone derivatives, ethyl chloroacetate and thiosemicarbazide, in ethanol at room temperature presence copper supported hydroxyapatite-encapsulated-γ-Fe2O3 (γ-Fe2O3@HAp@CPTMS@AT@Cu(ӀI)) as new magnetically recyclable heterogeneous...

A (pyridazinyl)acetate derivative was reacted with thiosemicarbazide and hydrazine hydrate to yield spiropyridazinone and acetohydrazide derivatives, respectively. The acetohydrazide derivative was used as a starting material for synthesizing some new heterocyclic compounds such as oxoindolinylidene, dimethylpyrazolyl, methylpyrazolyl, oxopyrazolyl, cyanoacetylacetohydrazide and oxadiazolylacet...

Antimicrobial screening of several novel pyrazolothiazol-4(5H)-one derivatives (3a-3j) has been performed. Reaction of aromatic aldehydes with aromatic ketones yielded starting chalcones (1a-1j) which have been subsequently reacted with thiosemicarbazide for obtaining N-thiocarbamoylpyrazole derivatives (2a-2j). These were further cyclized to pyrazolothiazol-4(5H)-one derivatives (3a-3j) in the...

Abstract Tautomerism is one of the most important phenomena to consider when designing biologically active molecules. In this work, we use NMR spectroscopy, IR, and X-ray analysis as well quantum-chemical calculations in gas phase a solvent study tautomerism 1- (2-, 3- 4-pyridinecarbonyl)-4-substituted thiosemicarbazide derivatives. The tautomer containing both carbonyl thione groups turned out...

In this study, 1-(5-Methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)ethan-1-one, was reacted with Thiosemicarbazide, alkyl carbodithioate and benzaldehyde to give thiosemicarbazone, alkylidenehydrazinecarbodithioate and 3-phenylprop-2-en-1-one-1,2,3-triazole derivatives. The 1,3,4-thiadiazole derivatives containing the 1,2,3-triazole moiety were obtained via reaction of alkylidenecarbodithioate with h...

A synthesis of some new thiosemicarbazide like acetyl hexan thiosemicarbazide by condensation of cyclohexylmethylketone with thiosemicarbazide is carried out. And their metal complexes were synthesized by condensation of acetylhexan thosemiocarbazide and different transition metal chloride salt of Cu(II), Co(II), Ni(II),Cd(II),Zn(II),Hg(II) and Fe(III) their characterization are done by differe...

A series of new thiosemicarbazones derived from natural diterpene kaurenoic acid were synthesized and tested against the epimastigote forms of Trypanosoma cruzi to evaluate their antitrypanosomal potential. Seven of the synthesized thiosemicarbazones were more active than kaurenoic acid with IC₅₀ values between 2-24.0 mM. The o-nitro-benzaldehyde-thiosemicarbazone derivative was the most active...

Aldol condensation reaction between 3-indolaldehyde 1 and 4-methoxyacetophenone 2 afforded chalcone compounds 3. This compound was reacted with some different reagents such as hydrazine hydrate, phenyl hydrazine, thiosemicarbazide, hydroxylamine, ethyl cyanoacetate, urea and thiourea to give pyrazolines 4a, 4b, 5a, 5b, 6, oxazoline 7, Michael adduct 8, pyranone 9, and oxo 14a and thiopyrimidine...

A series of zingerone?thiohydantoin hybrids were synthesized from O-alkyl zingerone derivatives by cyclocondensation with thiosemicarbazide in a two-step reaction. The obtained new potentially bioactive compounds structurally characterized IR and NMR spectroscopy, as well elemental HRMS analysis. In addition, their antimicrobial vitro anticancer activities tested. tested showed low to moderate ...

Condensation of ethylaceto acetate (EAA) with resorcinol in concentrated H2SO4 afforded 7-hydroxy-4-methyl coumarin (1), which on reaction with thiosemicarbazide in anhydrous pyridine yielded 7-hydroxy-4-methyl-quinolinyl [1,5-c]-mercaptotriazole (2). Reaction of 2 with formaldehyde solution and amino acid in ethanol yielded 7-hydroxy-4-methyl-8-(N-methyl-aminoacid)-quinolinyl [1,5-c]-2''-merca...