PURPOSE: To analyze the healing effects of stromal vascular fraction (SVF) application compared to wound dressing with 2% silver sulfadiazine in full thickness burn wounds in rats. METHODS: Animals were divided into two groups: 2% silver sulfadiazine group and SVF group. Both groups received occlusive bandages while the first one was treated with 2% silver sulfadiazine and the latter was tr...

Infection is the primary source of mortality in burn patients. One of the main treatment methods of burn wound infections is topical antimicrobial therapy, in which drugs have to permeate a dead tissue called eschar. Unfortunately, most antimicrobial agents can not permeate eschar in therapeutic levels. Surprisingly, permeation properties of this barrier and effects of chemical or environmental...

Infection is the primary source of mortality in burn patients. One of the main treatment methods of burn wound infections is topical antimicrobial therapy, in which drugs have to permeate a dead tissue called eschar. Unfortunately, most antimicrobial agents can not permeate eschar in therapeutic levels. Surprisingly, permeation properties of this barrier and effects of chemical or environmental...

Introduction: Burns are one of the most common household and industrial injuries. There are evidences which demonstrate the therapeutic properties of honey and Aloe vera. We evaluated the topical influences of this material and nano zinc combination on healing the wounds caused by third-degree burns. Materials and methods: 32 balb/c mice divided into a control group (without treatment), grou...

The purpose of present study was determination of number changes of mast cells in a honey treated experimental model of third degree burn. A third degree burn was made in 24 adult female rats by direct contact of skin with boiling water for 8 seconds. Rats were divided randomly into four groups. Group 1: Burns of this group remained untreated (control group). Groups 2 and 3: Burns of these grou...

The purpose of present study was determination of number changes of mast cells in a honey treated experimental model of third degree burn. A third degree burn was made in 24 adult female rats by direct contact of skin with boiling water for 8 seconds. Rats were divided randomly into four groups. Group 1: Burns of this group remained untreated (control group). Groups 2 and 3: Burns of these grou...

BACKGROUND It has been shown that topical nanoliposomal formulations improve burn healing process. On the other hand, it has been shown that liposomal formulations increase drug deposition in the normal skin while decrease their systemic absorption there is not such data available for burn eschar. Present investigation studies permeation of clindamycin phosphate (CP) through burn eschar from l...

A burn case of 42-year-old female patient due to pressure cooker explosion associated with mandibular fracture is presented. After early tangential excision of the deep second- and third-degree-burn areas, a split-thickness skin grafting was applied. Open reduction and internal fixation therapy with miniplate system were done for linear symphysis fracture. As much as we know, there was no repor...

Antimicrobial therapy remains to be the most important method of wound infection treatment. Systemically administered antimicrobials may not achieve therapeutic level in wound. On the other hand, in the absence of surgical debridement (due to any reason), most topically applied antimicrobials cannot penetrate the wound in therapeutic amount due to the presence of eschar. Burn eschar is a protei...