background: recurrent pregnancy loss is (rpl) a heterogeneous condition. while the role of acquired thrombophilia has been accepted as an etiology for rpl, the contribution of specific inherited thrombophilic gene polymorphisms to the disorder has been remained controversial. methods: one hundred women with a history of two or more consecutive abortions and 100 women with at least two live birt...

BACKGROUND Thrombophilia is a main predisposition to thrombosis due to a procoagulant state. Several point mutations play key roles in blood-clotting disorders, which are grouped under the term thrombophilia. These thrombophilic mutations are methylenetetrahydrofolate reductase (MTHFR, C677T, and A1298C), factor V Leiden (G1691A), prothrombin gene mutation (factor II, G20210A), and plasminogen ...

Inherited thrombophilia is thought to increase the risk of pregnancy related venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE). Pregnancy is a hypercoagulable state due to the increased concentration of coagulation factors, decreased natural anticoagulants and fibrinolytic activity1. The pregnant woman is therefore at increased risk for VTE and this ...

We read the article by Ozturk et al. [1], in which they reported the frequency of some thrombophilic mutations in eastern Turkey. The authors have defined single nucleotide gene variations of factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T as thrombophilic mutations. However, as current scientific data do not support an increased risk of thrombosis in...

OBJECTIVE To investigate the impact of inherited thrombophilic factors on the gestational outcome of unselected pregnant women. METHOD A total of 392 women with spontaneous pregnancy were investigated for Factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations. Adverse pregnancy outcomes were recorded. RESULTS Thrombophilic genotypes were significantly higher in women with placental...

Antiphospholipid syndrome (APS) is a thrombophilic condition leading to multiple complications. Primary APS rarely causes primary adrenal insufficiency, but it can be life-threatening. In the present report, patient presents with symptoms and signs of insufficiency subsequent hormone level tests radiological findings led diagnosis insufficiency.