hydrolysis. Protease was purified 285-fold from thyroid supernatant fraction by DEAWCellulose and Sephadex G-200 chromatography. The protein sedimented as a single component in the analytical centrifuge with a sedimentation constant of 3.6 S. Enzyme activity of the purified enzyme was increased by mercaptoethanol and cysteine, and inhibited by n-chloromercuribenzoate. A specific antibody:agains...

The relationship between thyroid auto-immunity and the presence of lymphocytes in the thyroid gland has been analysed in patients with Graves' disease, toxic adenoma, and non-toxic nodular goitre. In all these conditions circulating antibody to thyroglobulin was significantly associated with lymphocytic infiltration. No similar correlation was established in the case of the complement-fixing an...

The preparation of stable formolized sheep cells coated with thyroglobulin and their use for the detection of auto-antibodies in human thyroiditis is described. This provides an easy laboratory test which gives results closely comparable with those using fresh tanned cells. The agglutination titres do not closely parallel the antibody content of the serum but a good correlation may be obtained ...

Several decades ago, surgeons tried to solve the problem of hypoparathyroidism with auto transplant of parathyroid tissue during surgery. The transplant of autologous parathyroid glands was first described, a more than a 100 of years ago in animal models by Halsted, with 60% of success when implant parathyroids of dogs in rectus abdominis [3]. In thyroid surgery was first described in 1926 by L...

precipitation. These three methods correlate well. The electrophoretic method was found to be the most suitable for the study of this antibody. Antibodies to gastric mucosa were demonstrated by complement fixation and immunofluorescence. The two methods gave good correlation, the latter being more sensitive. The antigen was localized in the cytoplasm of the parietal cells and was recovered in t...

Background: Premature ovarian failure (POF) is a disorder of multi causal etiology. Autoimmunity has been proposed as a mechanism for some cases of ovarian follicle dysfunction which is evident in POF. The aim of this study was to identify the level of auto-antibodies in POF and familial POF patients. Materials and Methods: In this study, auto-antibodies including anti-ovarian antibody (AOA), a...

The best method of preventing hypoparathyroidism after thyroidectomy is to keep parathyroid glands in situ. However, hypoparathyroidism still regularly occurs with the existing parathyroid classification system, and the incidence of permanent hypoparathyroidism has not been reduced. We created a novel system for classifying parathyroid glands that can guide parathyroid preservation in thyroidec...

Hyperthyroidism can be defined as the status of over production thyroid hormones: tri-iodothyronine (T3) and thyroxine (T4) a results gland dysfunction. The aim current study was to investigate association between abnormalities hormones (T3 T4) serum levels auto-antibodies: anti-thyroid peroxidase (TPO-Ab) stimulating hormone receptor (TR-Ab) state hyperthyroidism. Blood samples were collected ...

Thyroid cancer can be associated with thyrotoxicosis caused by Graves' disease, toxic multinodular goiter, or autonomously functioning thyroid adenoma. The objective of this study was to summarize current evidence regarding the association of thyroid cancer and hyperthyroidism, particularly with respect to the type of hyperthyroidism found in some patients, and whether this affects the outcome ...

▼ Thyroid cancer can be associated with thyrotoxicosis caused by Graves’ disease, toxic multinodular goiter, or autonomously functioning thyroid adenoma. The objective of this study was to summarize current evidence regarding the association of thyroid cancer and hyperthyroidism, particularly with respect to the type of hyperthyroidism found in some patients, and whether this aff ects the outco...