The steady-state concentrations of metronidazole and tinidazole in male genital tissues were analyzed in patients subjected to elective gonadal surgery. The nitroimidazoles were administered orally at 500 mg every 8 h, beginning 5 days before the operation. Eight hours after the last dose, the concentrations of tinidazole were 24.1 +/- 2.5 micrograms (mean +/- standard error of the mean)/g of p...

Metronidazole, ornidazole, tinidazole, and secnidazole are 5-nitroimidazoles. The purpose of this work was to propose a new economical TLC–densitometric method evaluate the chemical stability metronidazole, secnidazole, tinidazole under stress conditions. A forced degradation study performed on silica gel aqueous solutions at various pH values; were prepared in saline hydrogen peroxide, respect...

Tinidazole (1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitroimidazole) was first introduced into clinical medicine in 1967 and has been used in Europe, Australia, Asia and in a number of developing countries for decades. It was approved by the FDA for the treatment of protozoal infections like trichomoniasis, giardiasis, intestinal amoebiasis, amoebic liver abscess. It is also very effective for bac...

PURPOSE to compare the efficacy of tinidazole and cephazolin on the febrile and infectious morbidity of post vaginal and abdominal hysterectomy antibiotic prophylaxis. METHODS randomized clinical study, where women admitted to hospital for hysterectomy were randomly allocated in one of the following antibiotic prophylaxis groups: Group C (2 g of IV cephazolin in the anesthetic induction); Gro...

UNLABELLED Triple therapy is accepted as the treatment of choice for H. pylori eradication. In industrialized countries, a proton pump inhibitor plus clarithromycin and amoxicillin or nitroimidazole have shown the best results. Our aims were: 1. To study the eradication rate of the association of a proton pump inhibitor plus tinidazole and clarithromycin on H. pylori infection in our population...

Pharmacodynamic studies of Helicobacter pylori exposed to metronidazole and tinidazole alone and in combination with clarithromycin were performed by bioluminescence assay of intracellular ATP. The pharmacodynamic parameter control-related effective regrowth time (CERT) was used. CERT is defined as the time required for the resumption of logarithmic growth and a return of the level of growth to...

Relevance . Successful treatment of endo-perio lesions depends on the thorough clinical assessment, accurate diagnosis and structural approach to planning periodontal endodontic treatment. Aim – provide laboratory evidence about effectiveness ciprofloxacin-and-tinidazole-containing antibiotic in comprehensive with a primary disease which secondarily affects pulp. Materials methods We examined 2...