We have previously reported the presence of a cardiac kinin-generating enzyme (CKGE) in human cardiac tissue. The present study was undertaken to examine the subcellular localization and the biochemical properties of this system in rat cardiac tissue. Cardiac bomogenate (20 mg) was incubated with beattreated plasma substrate and citrate-pbospbate buffer (pH 5.3) in the presence of peptidase inh...

Background: Myeloperoxidase (MPO), which is abundantly expressed in neutrophils, catalyzes the formation of a number of reactive oxidant species. However, evidence has emerged that MPO-derived oxidants contribute to tissue damage and initiation and propagation of inflammatory diseases, particularly, cardiovascular diseases. Therefore, studying the regulatory mechanisms of the enzyme activity is...

Background Chronic treatment with high doses of angiotensin-converting enzyme (ACE) inhibitors prolongs survival after myocardial infarction. Since the plasma reninangiotensin system (RAS) is not consistently activated in the chronic phase after myocardial infarction, the beneficial effects of ACE inhibition have been attributed, in part, to inhibition of an activated tissue RAS. However, a rel...

Repair of tissue after injury depends on a series of concerted but overlapping events including, inflammation, re-epithelialization, neovascularization and synthesis and stabilization of a fibrous extracellular matrix (ECM) that is remodeled to emulate normal tissue over time. Particular members of the transglutaminase (TG) family are upregulated during wound healing and act as a novel class of...

1. An extracellular, proteolytic enzyme has been observed in more than 30 strains of beta type, aerobic and facultative hemolytic streptococci. 2. The enzyme is readily demonstrable in sterile filtrates of cooked meat cultures. 3. No gas or foul odor is produced. 4. It is partially inactivated by exposure to about 60 degrees C. for 45 minutes or longer. 5. The enzyme manifests itself in cooked ...

background: myeloperoxidase (mpo), which is abundantly expressed in neutrophils, catalyzes the formation of a number of reactive oxidant species. however, evidence has emerged that mpo-derived oxidants contribute to tissue damage and initiation and propagation of inflammatory diseases, particularly, cardiovascular diseases. therefore, studying the regulatory mechanisms of the enzyme activity is...

background: the purpose of this comparative study was to detect superoxide dismutase (sod) activities in fasciola hepatica, f. gigantica parasites, infected and healthy liver tissues in order to determine of species effects and liver infection on sods activity level. methods: fasciola spp. parasites and sheep liver tissues (healthy and infected liver tissues), 10 samples for each, were collecte...

introduction: to determine an indicator for triclabendazole (tcbz) efficacy, alanine aminotransferase (alt) activity in fasciola hepatica (iranian isolate) parasite in presence and absence of tcbz was evaluated by an in vitro cultivation method. also, alt enzyme activity between none and parasitized-infected sheep liver tissues was assessed. method:  the sheep livers were collected and transfer...

introduction: hydatid cyst disease is caused by the protoscolices of echinococcus granulosus. alkaline phosphatase (alp) enzyme is required for metabolism, physiology, immunology, and nutrients absorption in parasite. the aim of this study was to compare the level of alp activity (as a pathological biomarker) in hydatid cyst protoscolices (hcp) with that of sheep liver tissue and to determine t...