نتایج جستجو برای: toxic peptides

تعداد نتایج: 154826  

Journal: :The Plant cell 1994
H Y Steiner W Song L Zhang F Naider J M Becker G Stacey

An Arabidopsis peptide transport gene was cloned from an Arabidopsis cDNA library by functionally complementing a yeast peptide transport mutant. The Arabidopsis plant peptide transporter (AtPTR2) allowed growth of yeast cells on dipeptides and tripeptides but not peptides four residues and higher. The plant peptide transporter also conferred sensitivity to a number of ethionine-containing, tox...

Journal: :Toxicon : official journal of the International Society on Toxinology 2006
Bora Inceoglu Jozsef Lango Alina Rabinovich Paul Whetstone Bruce D Hammock

Scorpion venom is composed among other things of a large number of neurotoxic peptides affecting all major types of ion channels. The majority of the toxicity of the venom is attributed to the presence of these peptides. In our previous studies using a combination of HPLC and mass spectrometry, we showed that birtoxin like peptides are the major peptidic components of the venom of Parabuthus tr...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
M Britschgi C E Olin H T Johns Y Takeda-Uchimura M C LeMieux K Rufibach J Rajadas H Zhang B Tomooka W H Robinson C M Clark A M Fagan D R Galasko D M Holtzman M Jutel J A Kaye C A Lemere J Leszek G Li E R Peskind J F Quinn J A Yesavage J A Ghiso T Wyss-Coray

A number of distinct beta-amyloid (Abeta) variants or multimers have been implicated in Alzheimer's disease (AD), and antibodies recognizing such peptides are in clinical trials. Humans have natural Abeta-specific antibodies, but their diversity, abundance, and function in the general population remain largely unknown. Here, we demonstrate with peptide microarrays the presence of natural antibo...

2014
Christian Zimmermann Silvia Rudloff Günter Lochnit Sevgi Arampatzi Wolfgang Maison Klaus-Peter Zimmer

SCOPE Celiac disease is an autoimmune disorder caused by failure of oral tolerance against gluten in genetically predisposed individuals. The epithelial translocation of gluten-derived gliadin peptides is an important pathogenetic step; the underlying mechanisms, however, are poorly understood. Thus, we investigated the degradation and epithelial translocation of two different gliadin peptides,...

2015
Biljana Mojsoska Håvard Jenssen Guangshun Wang

The purpose of this paper is to introduce and highlight a few classes of traditional antimicrobial peptides with a focus on structure-activity relationship studies. After first dissecting the important physiochemical properties that influence the antimicrobial and toxic properties of antimicrobial peptides, the contributions of individual amino acids with respect to the peptides antibacterial p...

Journal: :Biointerface Research in Applied Chemistry 2021

Proteins and peptides of housefly larvae (HFL) have potential applications in food therapy. The fate HFL proteins following human gastrointestinal (GI) digestion is unknown. This study adopted a computational approach to discover released from upon GI digestion. In silico eight major 783 peptides. comprised 243 exhibiting 13 types bioactivities. Ninety-two single-function anti-dipeptidyl peptid...

2017
Qian Li Mengchuan Xu Yali Cui Chunqian Huang Manji Sun

The membrane-permeable peptides (MPP) such as undecapeptides TAT (YGRKKRRQRRR) and CTP (YGRRARRRRRR) have been receiving much attention for delivering various kinds of low membrane-permeability materials in vitro and in vivo. We have successfully used MPP in carrying various proteins through blood-brain barrier (BBB) in treatment of many kinds of nervous diseases. However, people always concent...

2014
Jean-Luc Boevé Raoul Rozenberg Akihiko Shinohara Stefan Schmidt

Toxic peptides containing D-amino acids are reported from the larvae of sawfly species. The compounds are suspected to constitute environmental contaminants, as they have killed livestock grazing in areas with congregations of such larvae, and related larval extracts are deleterious to ants. Previously, two octapeptides (both called lophyrotomin) and three heptapeptides (pergidin, 4-valinepergi...

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