How sexual regulators translate global sexual fate into appropriate local sexual differentiation events is perhaps the least understood aspect of sexual development. Here we have used ChIP followed by deep sequencing (ChIP-seq) to identify direct targets of the nematode global sexual regulator Transformer 1 (TRA-1), a transcription factor acting at the interface between organism-wide and cell-s...

With the rapid increase in urban development, it is critical to utilize dynamic sensor streams for trac understanding, especially in larger cities where route planning or infrastructure planning is more critical. Œis creates a strong need to understand trac paŠerns using ubiquitous sensors to allow city ocials to be better informed when planning urban construction and to provide an understan...

Several studies in network tra c characterization have concluded that network tra c is self-similar and therefore is not readily amenable to statistical multiplexing in a distributed computing system. This paper examines the e ects of the TCP protocol stack on network tra c via an experimental study on the di erent implementations of TCP. We show that even when aggregate application tra c smoot...

Computer simulation of tra c is a widely used method in research of tra c modelling, planning and development of tra c networks and systems. Vehicular tra c systems are of growing concern and interest globally and modelling arbitrarily complex tra c systems is a hard problem. In this article we review some of the tra c simulation software applications, their features and characteristics as well...

PURPOSE To evaluate agonistic TRA-8 monoclonal antibody to human death receptor 5 (DR5) and gemcitabine in vitro and in an orthotopic pancreatic cancer model. EXPERIMENTAL DESIGN Pancreatic cancer cell lines were screened for DR5 expression, cytotoxicity, and apoptosis induced by TRA-8, gemcitabine, or gemcitabine and TRA-8. An orthotopic model of pancreatic cancer was established in severe c...

A Bandwidth Control Scheme for Connectionless ATM Tra c with Multiple Tra c Classes J org Liebeherr y Ian F. Akyildiz z Debapriya Sarkar ? y Computer Science Department, University of Virginia, Charlottesville, VA 22903. z School of ECE, Georgia Institute of Technology, Atlanta, GA 30332. ? Hughes Network Systems, Hughes Network Systems, Germantown, MD 20876. Abstract A bandwidth control mecha...

OBJECTIVES To study the causes of and to develop a risk score for failure of transradial approach (TRA) for percutaneous coronary intervention (PCI). BACKGROUND TRA-PCI failure has been reported in 5% to 10% of cases. METHODS TRA-PCI failure was categorized as primary (clinical reasons) or crossover failure. Multivariate analysis was performed to determine independent predictors of TRA-PCI ...

Transformer (TRA) promotes female development in several dipteran species including the Australian sheep blowfly Lucilia cuprina, the Mediterranean fruit fly, housefly and Drosophila melanogaster. tra transcripts are sex-specifically spliced such that only the female form encodes full length functional protein. The presence of six predicted TRA/TRA2 binding sites in the sex-specific female intr...

objectives: the aim of this study was to compare polymerization depth of two bulk-fill and one conventional composite cured for different times. methods: this in vitro experimental study was conducted on 54 composite samples (2×4×10mm) fabricated of tetric n-ceram bulk-fill, x-tra fil bulk-fill, and grandio conventional composite cured for 20, 30, and 40 seconds. the microhardness of samples wa...

BACKGROUND Vitamin A is necessary for kidney development and has also been linked to regulation of solute and water homeostasis and to protection against kidney stone disease, infection, inflammation, and scarring. Most functions of vitamin A are mediated by its main active form, all-trans retinoic acid (tRA), which binds retinoic acid receptors (RARs) to modulate gene expression. We and others...