conventional transdermal drug delivery systems (tdds) have been designed for drug delivery through the skin. these systems use the permeability property of stratum corneum, the outermost surface layer of the skin. applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...

nicotine transdermal systems are being used as an aid to smoking cessation programs. as the kinetics of nicotine delivery is important in success of a smoking cessation program, rapid and high input of nicotine is required, which is not possible by passive methods and requires enhancement strategies such as iontophoresis. iontophoretic permeation, of nicotine looks promising, based on published...

Article history: Received on: 07/11/2013 Revised on: 21/12/2013 Accepted on: 16/01/2014 Available online: 27/02/2014 Nisoldipine is used for treatment of hypertension and angina pectoris. However, it suffers from very low bioavailability due to its extensive pre-systemic metabolism. This together with its low dose made it excellent candidate for transdermal delivery. Accordingly, the aim of thi...

   Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...

The present article is a descriptive study of the performances of ethosomes and proniosomes as specialized delivery systems for transdermal drug delivery system. Vesicular systems, such as ethosomes and proniosomes are used in cosmetic and pharmaceutical products to encapsulate ingredients, to protect ingredients from degradation, to increase bioavailability, and to improve cosmetic performance...

Nowadays about 74% of drugs are taken orally and found not to be as effective required. To improve such characters transdermal drug delivery system was emerged. Drug through the skin attain a systemic effect is commonly known differs from traditional topical delivery. Transdermal systems (TDDS) dosage forms involves transport viable epidermal or dermal tissues for local therapeutic while very m...

Transdermal Drug Delivery System (TDDS) is one of the systems lying under the category of controlled drug delivery, in which the aim is to deliver the drug through skin in a predetermined and controlled rate. Hypertension is one of the common disorder for the mankind. It is not a disease in itself, but is an important risk factor for cardiovascular mortality and morbidity. The present article d...

the aim of the present study was to develop and investigate the feasibility of delivering nebivolol as a transdermal patch by iontophoresis. the passive and electrically assisted transdermal delivery of nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. because of its extensive hepatic metabolism and low dos...

the aim of the present study was to investigate the influence and the mechanisms of cineoleand terpineol on the in-vitro transdermal delivery of huperzine a from microemulsions, andtheir potential synergistic effect on the permeation enhancement. the transdermal deliveryof huperzine a from microemulsions with different concentrations of cineole and terpineolthrough the rat abdominal skin was de...

In past few decades, scientists have made tremendous advancement in the field of drug delivery systems (DDS), through transdermal pathway, as the skin represents a ready and large surface area for delivering drugs. Efforts are in progress to design efficient transdermal DDS that support sustained drug release at the targeted area for longer duration in the recommended therapeutic window without...