This study examines outcome measures of abstinence among studies reporting 12-month outcomes of the nicotine transdermal patch using different measures of effectiveness. This was achieved by reviewing published randomized controlled studies reporting 1-year abstinence rates of the nicotine transdermal patch. Comparisons are made across studies of three outcome measures used to report abstinence...

      Insulin-loaded biodegradable chitosan nanoparticle was prepared by the polyelec-trolyte complex formation method. The prepared nanoparticles were in the size of 110 nm and had high entrapment (91.0%) capacity. The transdermal nanoinsulin was characterized by in vivo hypoglycemic effects. Plasma glucose was decreased to the range of 80.34 to 96.74 mg/dl, and insulin levels were in...

The present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) using a D-optimal mixture design. The prepared transdermal patches were subjected to different physicochemical evaluation. The surface topography of the patches was examined by scanning electron microscopy (S...

The present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) using a D-optimal mixture design. The prepared transdermal patches were subjected to different physicochemical evaluation. The surface topography of the patches was examined by scanning electron microscopy (S...

Today patients with mild to moderate Alzhiemer's disease (AD) have a treatment approach choice: oral or transdermal delivery. The aim of this review was to provide a concise, comprehensive overview of the clinically relevant safety, tolerability and efficacy information available for the rivastigmine transdermal system. Relevant articles were identified through a MEDLINE search of publications ...

Background: The aim of this prospective randomized clinical trial was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in FET cycles, that is, oral estradiol and 17 β-estradiol transdermal patch. Materials and Methods: A total number of 90 patients were scheduled for FET. In the study group (n=45), 17-B estradi...

1) Study's objective is "To assess rotigotine transdermal patch for the perioperative management of moderate to severe RLS". To assess what? Efficacy? Feasibility of use? The objective of this posthoc analysis was to assess the feasibility of use of rotigotine transdermal patch for the perioperative management of moderate to severe RLS. Efficacy data for the entire study population, including p...

BACKGROUND The purpose of this study was to develop a transdermal ligustrazine patch containing a stable formulation and with good entrapment efficiency, release rate, and transdermal absorption. METHODS Ligustrazine ethosomes were prepared by ethanol injection-sonication, with entrapment efficiency as an indicator. Using acrylic resin as the primary constituent, the ligustrazine ethosome pat...

PURPOSE To determine whether (1) tailored nicotine patch therapy that is based on smoking rate can be carried out in a multisite oncology investigative group practice setting, (2) long-term use of bupropion reduces the rate of relapse to smoking in smokers who stop smoking with nicotine patch therapy, and (3) bupropion can initiate smoking abstinence among smokers who have failed to stop smokin...