Anesthetized dogs were studied to characterize the renal hemodynamic response to acute, transient hypoxemia and to determine the role of renal prostaglandins (PGE and PGF) in that response. Acute hypoxemia of 10 minutes duration (mean arterial Po2 32 ± 9 torr) induced a reversible increase in renal blood flow (RBF) (measured by electromagnetic flow probe) and mean arterial pressure (MAP) with a...

Anesthetized dogs were studied to characterize the renal hemodynamic response to acute, transient hypoxemia and to determine the role of renal prostaglandins (PGE and PGF) in that response. Acute hypoxemia of 10 minutes duration (mean arterial Po2 32 ± 9 torr) induced a reversible increase in renal blood flow (RBF) (measured by electromagnetic flow probe) and mean arterial pressure (MAP) with a...

A gender dimorphic immune response has been observed after trauma and severe hemorrhage, a condition believed to be associated with tissue hypoxia. Although studies have shown that hypoxemia per se in males causes a systemic inflammatory response, it is unclear if the inflammatory response to hypoxemia exhibits gender dimorphic characteristics. To study this, male and female C3H/HeN mice in the...

lung injury (ALI) occurs in 20–25% of the patients with isolated brain injury and is associated with a poor neuro-logical outcome [1]. Patients with ALI admitted to the intensive care unit (ICU) often develop neuropsychological changes, as do patients recovering from acute respiratory distress syndrome (ARDS) [2]. This implies that there are close interactions between the brain and lung. The pr...

Hypoxemia depresses cell-mediated immune functions in males, whereas proestrous females do not show such a depression. We hypothesized that elevated systemic estradiol levels in proestrous females prevent hypoxemia-induced immune depression. To study this hypothesis, male C3H/HeN mice were pretreated with 17 beta-estradiol (E(2), 40 microg/kg body wt sc) or vehicle for 3 days before induction o...

Long-term oxygen therapy (LTOT) improves prognosis in patients with COPD and chronic severe hypoxemia. The efficacy in moderate hypoxemia (tension of arterial oxygen; on air, 7.4-8.0 kPa) was questioned by a recent large trial. We reviewed the evidence to date (five randomized trials; 1,191 participants, all with COPD). Based on the current evidence, the survival time may be improved in patient...

Anesthetized dogs were studied to characterize the renal hemodynamic response to acute, transient hypoxemia and to determine the role of renal prostaglandins (PGE and PGF) in that response. Acute hypoxemia of 10 minutes duration (mean arterial Po2 32 ± 9 torr) induced a reversible increase in renal blood flow (RBF) (measured by electromagnetic flow probe) and mean arterial pressure (MAP) with a...

Hypoxemia is a common finding in many diseases of the lung. The degree of hypoxemia depends upon which aspect of pulmonary function is deranged as well as upon the severity of the abnormality. The degree of hypoxemia, the presence or absence of carbon dioxide retention, and the effects of exercise and oxygen breathing on the hypoxemia provide information about the nature and extent of the under...