PURPOSE/OBJECTIVES To describe the biologic process of angiogenesis and the potential role of antiangiogenesis therapy in cancer treatment. DATA SOURCES Published articles, conference proceedings, and computerized databases. DATA SYNTHESIS Angiogenesis is the development of blood vessels. Antiangiogenic agents prevent the development of blood vessels, therefore preventing one mode of cancer...

Within the framework of two phase III clinical trials, the superior results of concomitant chemotherapy and radiotherapy in the treatment of patients with locally advanced anal carcinoma were demonstrated. A further phase III clinical trial showed that the role of mitomycin C as part of the concomitant chemotherapy in combination with 5-fluorouracil appeared to be essential in obtaining a highe...

Although in centers where pancreatectomy is performed frequently, associated morbidity and mortality rates have improved, long-term outcomes in pancreatic adenocarcinoma patients remain poor when surgery is the sole therapeutic modality. The impact of adjuvant chemotherapy on survival in patients with localized pancreatic cancer remains incompletely defined. The European Study Group for Pancrea...

Despite successful new treatment strategies developed in the past few decades aimed at different pathomechanisms of myocardial disease,1 morbidity and mortality due to heart failure and its complications remain a clinical reality. Among the treatment strategies available, the maintenance of contractile mass that is determined by the number of myocytes and the degree of cellular hypertrophy is a...