background and purpose: cutaneous infections arise from a homogeneous group of keratinophilic fungi, known as dermatophytes. since these pathogenic dermatophytes are eukaryotes in nature, use of chemical antifungal agents for treatment may affect the host tissue cells. in this study, we aimed to evaluate the antifungal activity of actinomyces species against trichophyton mentagrophytes (abbrevi...

DNA sequencing analyses have demonstrated relatively limited polymorphisms within the fungal internal transcribed spacer (ITS) regions among Trichophyton spp. We sequenced the ITS region (ITS1, 5.8S, and ITS2) for 42 dermatophytes belonging to seven species (Trichophyton rubrum, T. mentagrophytes, T. soudanense, T. tonsurans, Epidermophyton floccosum, Microsporum canis, and M. gypseum) and deve...

non-steroidal anti-inflammatory drugs (nsaids) are the most common pharmacological group that has three primary therapeutic effects including anti-inflammatory, anti-pyrexia, and analgesia. in this study, seven of nsaids were tested against two species of skin pathogenic fungi (dermatophytes). percentage inhibition was determined for effective agents. diclofenac, aspirin and naproxen showed muc...

The effect of storage temperature on the viability of Trichophyton mentagrophytes in infected guinea pig skin scales was quantitatively evaluated for 182 days. Infected skin scales were stored, while protected from light, in glass containers with desiccant at four temperatures and sampled after saline treatment at various time intervals. No decrease in viability was observed for storage at 4 de...

Trichophyton rubrum and Trichophyton mentagrophytes complex, or Trichophyton spp. are the main etiologic agents of dermatophytosis, whose treatment is limited by the high cost of antifungal treatments, their various side effects, and the emergence of resistance amongst these species. This study evaluated the in vitro antidermatophytic activity of 23 crude extracts from nine plant species of sem...

Tinea incognito is a dermatophytosis with atypi-cal clinical manifestation in the absence of the typical " ringworm " (1). The term tinea incognito was originally used in 1968 by Ive and Marks in 14 patients with atypical dermatophytic infection caused by a previous steroid treatment (2). Since then, several cases of tinea incognito have been described after topical application of pimecrolimus ...

Bromocresol purple-milk solids-glucose medium, proposed by Fischer and Kane in 1971 (Mycopathol. Mycol. Appl. 43:169-180, 1971) as an aid in the rapid determination of Trichophyton rubrum and Trichophyton mentagrophytes, was evaluated across a wide range of isolates to determine its accuracy and efficacy in the clinical laboratory. Results showed that it facilitated accurate determination of ty...

The mechanism of action of efinaconazole, a new triazole antifungal, was investigated with Trichophyton mentagrophytes and Candida albicans. Efinaconazole dose-dependently decreased ergosterol production and accumulated 4,4-dimethylsterols and 4α-methylsterols at concentrations below its MICs. Efinaconazole induced morphological and ultrastructural changes in T. mentagrophytes hyphae that becam...