Secondary structure elements often mediate protein-protein interactions. Despite their low abundance in folded proteins, polyproline II (PPII) and its variant, the triple helix, are frequently involved in protein-protein interactions, likely due to their peculiar propensity to be solvent-exposed. We here review the role of PPII and triple helix in mediating hostpathogen interactions, with a par...

It has been shown that the nucleoporin ALADIN plays a significant role in the redox homeostasis of the cell, but its function in steroidogenesis contributing to adrenal atrophy in triple A syndrome remains largely unknown. In an attempt to identify new interaction partners of ALADIN, co-immunoprecipitation followed by proteome analysis was conducted in different expression models using the huma...

Complex diseases are often caused by the function of multiple genes, gene-gene (G×G) interactions as well as gene-environment (G×E) interactions. G×G and G×E interactions are ubiquitous in nature. Empirical evidences have shown that the effect of G×G interaction on disease risk could be largely modified by environmental changes. Such a G×G×E triple interaction could be a potential contributing ...

A single arginine residue within the RNA-binding domain of the human immunodeficiency virus Tat protein makes a critical sequence-specific contact to TAR RNA. Arginine as the free amino acid also binds specifically to TAR and induces a change in RNA conformation similar to that induced by Tat peptides. NMR and biochemical studies have suggested that the arginine-binding site is stabilized by a ...

In this paper, we study the electronic properties of a concentric triple quantum ring using exact diagonalization technique. The energy spectra and magnetization for a single electron and two electrons, in the presence of an applied magnetic field, are calculated and discussed. It is shown that, for two-interacting electrons, the period of Aharonov-Bohm oscillations decreases to the half of tha...

Through the triple–alpha process practically all of the carbon in our universe is synthesized as the ash of helium burning in red giants. The triple–alpha process proceeds trough the ground state of Be and though the 02+–state in C. We investigate the dependence of 02+–state and the production of carbon as a function of the strength of the underlying nucleon–nucleon interaction. This is perform...