BACKGROUND Triple-negative breast cancer is a subtype of breast cancer with aggressive tumor behavior and distinct disease etiology. Due to the lack of an effective targeted medicine, treatment options for triple-negative breast cancer are few and recurrence rates are high. Although various multi-gene prognostic markers have been proposed for the prediction of breast cancer outcome, most of the...

objective the mortality of patients with locally advanced triple-negative breast cancer (tnbc) is high, and pathological complete response (pcr) to neoadjuvant chemotherapy (nac) is associated with improved prognosis. this retrospective study was designed and powered to investigate the ability of 18f-fluorodeoxyglucose positron emission tomography/computed tomography (fdg-pet/ct) to predict pat...

background: triple-negative breast cancer (tnbc) carries a poor prognosis and therapeutic options are limited to date. the aim of this study was to investigate to what extent the epidermal growth factor receptor (egfr), vascular endothelial growth factor receptor 2 (vegfr2), hypoxia inducible factor-1 alpha (hif-1α) and insulin-like growth factor-1 receptor (igf-1r) are expressed in tnbc and to...

background: because of the reported poor prognosis and absence of effective and specific therapeutic approaches, triple-negative breast cancer (tnbc) tumors have remained as an important area of investigations for clinicians and researchers. the aim of this study was to determine the clinical, pathological, histological, prognostic features, and outcome associated with this type of breast cance...

The microstructure and softening behaviour have been investigated in an aluminum plate heavily deformed by equal channel angular extrusion and subsequently annealed at 170 °C. It is found that at this temperature the microstructure evolves by coarsening with no apparent signs of recrystallization even after 2 h of annealing. Both coarsening and softening are rapid within first 10 minutes of ann...

Purpose: Treatment options for patients with triple-negative breast cancer (TNBC) are largely limited to systemic chemotherapies, which have shown disappointing efficacy in the metastatic setting. Here, we undertook a comprehensive evaluation of the activity of ganetespib, a potent inhibitor of HSP90, in this

This investigation utilizes a matrix observation method to analyze triple helices. Firstly, by analyzing a unique Chinese academic phenomenon, the university-run enterprise (URE), a ‘cored model’ is proposed to complement the existing non-cored model of a triple helix study. The URE remains within the university administration, in contrast to the US spin-off firm that exits quickly. This differ...

PURPOSE To compare the clinical features, natural history, and outcomes for women with "triple-negative" breast cancer with women with other types of breast cancer. EXPERIMENTAL DESIGN We studied a cohort of 1,601 patients with breast cancer, diagnosed between January 1987 and December 1997 at Women's College Hospital in Toronto. Triple-negative breast cancers were defined as those that were ...

PURPOSE This study sought to assess the prevalence of common germline mutations in several genes engaged in the repair of DNA double-strand break by homologous recombination in patients with triple-negative breast cancers and hereditary non-triple-negative breast cancers. Tumors deficient in this type of DNA damage repair are known to be especially sensitive to DNA cross-linking agents (e.g., p...