Excess L-tryptophan (L-Trp) in the diet decreases fetal body weight. However, the relationship between L-Trp concentration and its effects on maternal, placental, and fetal growth are not well-understood. We investigated the effects of excess L-Trp intake on maternal, placental, and fetal growth. Female mice were fed a 20% casein diet (control diet) or control diet plus 2% or 5% L-Trp during ge...

We report a photochemical method for the chemoselective radical functionalization of tryptophan (Trp)-containing peptides. The exploits photoactivity an electron donor-acceptor complex generated between unit and pyridinium salts. Irradiation with weak light (390 nm) generates intermediates right next to targeted Trp amino acid, facilitating proximity-driven functionalization. This protocol exhi...

We examined the changes in serum, liver, kidney, brain, and muscle L-tryptophan (Trp) levels in rats with puromycin aminonucleoside (PAN) nephrosis following oral Trp administration in order to elucidate the fate of elevated Trp in the blood of PAN nephrotic rats with oral Trp administration in their body. Before administration, nephrotic rats had higher liver and kidney Trp contents and lower ...

The efficient biohybrid photocatalysts were prepared with different weight ratios of Fe2O3 and treated rape pollen (TRP). synthesized samples characterized by analytical techniques. results showed that carbonized had a three-dimensional skeleton granular uniformly covered the surface TRP. Fe2O3/TRP used for degradation Methylene Blue (MB) Escherichia Coli (E. coli) disinfection in water under v...

Most conjugates of plant hormones are inactive, and some function to reduce the active hormone pool. This study characterized the activity of the tryptophan (Trp) conjugate of jasmonic acid (JA-Trp) in Arabidopsis (Arabidopsis thaliana). Unexpectedly, JA-Trp caused agravitropic root growth in seedlings, unlike JA or nine other JA-amino acid conjugates. The response was dose dependent from 1 to ...

It is well known that the mutation of TRP-ML1 (transient receptor potential-mucolipin-1) causes mucolipidosis IV, a lysosomal storage disease. Given that lysosomal nicotinic acid adenine dinucleotide phosphate (NAADP)-Ca(2+) release channel activity is associated with TRP-ML1, the present study was designed to test the hypothesis that NAADP regulates lysosome function via activation of TRP-ML1 ...

The aim of the study was to evaluate the requirement for Trp in relation to diet composition in piglets in the period after weaning (BW range of 9 to 24 kg). Two Trp-deficient [relative to the Dutch (CVB, 1996) and NRC (NRC, 1998) requirement values for piglets of 10 to 20 kg of BW] basal diets were formulated: one based on corn and soybean meal and a second one based on wheat, barley, soybean ...

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain technique that considered valuable and promising for improving depressive symptoms in treatment-resistant depression (TRD). However, the exact mechanism by which rTMS ameliorates remains to be clarified. The aim of present study was analyzed changes metabolites patients with TRD treatment, especially focusing on kynureni...

During pregnancy, tryptophan (Trp) is required for several purposes, and Trp metabolism varies over time in the mother and fetus. Increased oxidative stress (OS) with high metabolic, energy and oxygen demands during normal pregnancy or in pregnancy-associated disorders has been reported. Taking the antioxidant properties of Trp and its metabolites into consideration, we made four hypotheses. Fi...