Background. Due to many physiological changes during pregnancy, interpretation of thyroid function tests needs trimester-specific reference intervals for a specific population. There is no normative data documented for thyroid hormones on healthy pregnant women in Iran. The present survey was conducted to determine trimester-specific reference ranges for serum TSH, thyroxine (TT4), and triiodot...

BACKGROUND Oral levothyroxine (l-T4 ) supplementation is commonly used to treat hypothyroid dogs. OBJECTIVES Investigate the plasma profile and pharmacokinetics of total thyroxine (tT4 ) after PO administration of a l-T4 solution and its clinical efficacy in hypothyroid dogs. ANIMALS Ten dogs with naturally occurring hypothyroidism. METHODS After hypothyroidism diagnosis and supplementati...

We evaluated three one-step (analog) and two two-step radioimmunoassay for free thyroxin (FT4), and a FT4 index calculated from the total T4 (TT4) and thyroxin-binding globulin (TBG) ratio for technical performance, for correlation with the reference FT4 method (equilibrium dialysis), and for dependence on TBG and albumin concentrations. The one-step methods (Amerlex, Coat-A-Count, and GammaCoa...

The effect of protein energy malnutrition (PEM) in the children on serum levels of total thyroxine (TT4), total triodothyronine (TT3) and thyrotropin (TSH) were evaluated. There were 107 children aged 2 to 60 months in the malnutrition group and 54 healthy age and sex matched controls. Serum TT4 and TT3 were all reduced in the malnutrition group. This decrease in TT3 was more significant (p < 0...

Stimulation of the thyroid with thyroid-stimulating hormone (TSH) is a potentially useful diagnostic dysfunction, but little known about response to TSH stimulation in bottlenose dolphins (Tursiops truncatus). To better characterize dolphin stimulation, five adult participated study. Dolphins voluntarily beached onto padded mat and were given 1.5 mg intramuscular injection human recombinant TSH...

The Texas Towers were a series of platforms installed off the U.S. East coast in the 1950’s to support early warning radar facilities. Texas Tower No. 4 (TT4) was installed in a water depth of 185 feet in 1957. At this time, TT4 was heralded as an ‘engineering marvel’, a major innovative ocean engineering accomplishment. However, problems in the structural integrity of the platform developed af...

We studied the relationships between polychlorinated biphenyls (PCBs) and thyroid hormones (THs) and retinol within two groups of female polar bears (Ursus maritimus), females with cubs of the year (FWCOY) and females without cubs of the year (FWOCOY), and within a group of males. Concentrations of five of the six quantified PCB congeners, i.e., PCB-99, PCB-153, PCB-156, PCB-180, PCB-194 (sigma...

BACKGROUND Perchlorate (ClO4(-)) is an environmental contaminant known to disrupt the thyroid axis of many terrestrial and aquatic species. ClO4(-) competitively inhibits iodide uptake into the thyroid at the sodium/iodide symporter and disrupts hypothalamic-pituitary-thyroid (HPT) axis homeostasis in rodents. OBJECTIVE We evaluated the proposed mode of action for ClO4(-)-induced rat HPT axis...

BACKGROUND Maternal depression during pregnancy has been studied less than depression in postpartum period. The aims of this study were to find out the prevalence of prepartum and postpartum depression and the risk factors associated in a cohort of Afro-Jamaican pregnant women in Jamaica. METHODS The Zung self-rating depression scale instrument was administered to 73 healthy pregnant women at...