world health organization (who) has reported that out of more than 10,000 of 250,000 tuberculosis afflicted children die annually. pulmonary tuberculosis is a research priority in our country, and diagnos-ing this disease especially in children who are known as the major transmitter of the disease is rather difficult. as a result, it was decided to conduct an overall assessment on this age grou...

BACKGROUND Repeat tuberculin skin tests may be false positive due to boosting of waned immunity to past mycobacterial exposure. We evaluated whether an ELISPOT test could identify tuberculosis (TB) contacts with boosting of immunity to non-tuberculous mycobacterial exposure. METHODOLOGY/PRINCIPAL FINDINGS We conducted tuberculin and ELISPOT tests in 1665 TB contacts: 799 were tuberculin test ...

T HE TUBERCULIN TEST IS THE MOST effective means for detecting tuberculous infection, and hence is an essential tool in ultimate eradication of the disease. In clinical practice it has been generally accepted that a positive tuberculin skin reaction indicates the possibility of tuberculosis, whereas a negative reaction, with few exceptions, rules out a tuberculous infection. Since the advent of...

A naturally occurring outbreak of Mycobacterium bovis infection in captive wild elk (wapiti) in Montana was confirmed by mycobacteriologic examination. Twenty-eight of 143 elk responded to M. bovis purified protein derivative (PPD) tuberculin injected intradermally in the cervical region (SCT). The results of comparative cervical tuberculin skin tests conducted within 9 days of SCT revealed gre...

We are unable to confirm the observations reported by Cole and Favour that passive transfer of plasma fractions containing alpha globulin (IV + V or IV-10) from tuberculin-sensitive guinea pigs confers delayed sensitivity to tuberculoprotein upon normal animals. In guinea pigs with chronic cervical adenitis due to infection with group C hemolytic streptococci, injection of fraction IV + V and r...

conclusion skin test anergy is uncommon among drug users and the ppd skin test may be reliably used for the identification of latent tb infection in the population. results a total of 221 patients (216 male, mean age 43.5 ± 14.3 years) were studied. tuberculin skin test results showed that 87 subjects (39.4%) tested positive for tb reactivity. reactivity to tetanus and candida antigens were obs...

The traditional concept that the tuberculin reaction when positive will remain so for the rest of the patient’s life has been widely accepted for many years. The present study was carried out to detect tuberculosis in its earliest phases by means of a positive tuberculin reaction in individuals who reacted negatively to previous test or tests. These positive patients were then followed by repea...

The value of tuberculin skin testing in the diagnosis of active tuberculosis remains uncertain. Interpretation of tuberculin tests would be easier if the tuberculin test profiles in different communities were accurately known. We reviewed 468 Mantoux test reactions in patients coming to Hospital Universiti Sains Malaysia with suspected tuberculosis. Eighty six percent of patients with active tu...