Background: Aberrant methylation of cytosine-guanine dinucleotide islands leads to inactivation of tumor suppressor genes in breast cancer. Tumor suppressor genes are unmethylated in normal tissue and often become hypermethylated during tumor formation, leading to gene silencing. We investigated the association between E-cadherin (CDH1) and estrogen receptor-α (ESRα) gene promoter methylation a...

Hypermethylation of CpG islands located in the promoter regions of genes is a major event in the development of the majority of cancer types, due to the subsequent aberrant silencing of important tumor suppressor genes. KLOTHO; a novel gene associated primarily with suppressing senescence has been shown to contribute to tumorigenesis as a result of its impaired function. Recently the relevance ...

background: aberrant methylation of cytosine-guanine dinucleotide islands leads to inactivation of tumor suppressor genes in breast cancer. tumor suppressor genes are unmethylated in normal tissue and often become hypermethylated during tumor formation, leading to gene silencing. we investigated the association between e-cadherin ( cdh1) and estrogen receptor-α (esrα) gene promoter methylation ...

The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...

background colorectal cancer (crc) is the second most common malignancy in the world.  however, its mortality rate can be reduced if diagnosed early. p33 ing1b is a tumor suppressor protein, which plays a role in growth control and apoptosis. suppression of p33 ing1b is associated with the loss of cellular growth control. however, p33 ing1b expression in crc and its correlations with clinicopat...

Gastric Cancer (GC) is the second most common cancer in the world and a leading cause of cancer-related mortality. Methylation of promoter CpG islands (CGIs) belonging to tumor suppressor genes causes transcriptional silencing of their corresponding genes leading to carcinogenesis and other disorders. Adenomatous Polyposis Coli (APC) a tumor suppressor gene is inactivated by methylation of prom...

Nanoenzymes In article 2300191 by Wenli Diao, Hui Wei, Hongqian Guo, and co-workers, a Zr-CeO nanozyme is developed to possess enhanced activities mimicking superoxide dismutase catalase. Via scavenging intracellular reactive oxygen species, exerts remarkable effects on diminishing myeloid-derived suppressor cells M2-TAM immunosuppression simultaneously, eventually boosts anti-tumor immune resp...