PART I. UNDERSTANDING THE FUNCTION AND REGULATION OF TUMOR SUPPRESSOR GENES 1 Utilizing NMR to Study the Structure of Growth-Inhibitory Proteins Francesca M. Marassi ........................................................................................ 3 2 Generation and Application of Phospho-Specific Antibodies for p53 and pRB Yoichi Taya, Kiichiro Nakajima, Kumiko Yoshizawa-Kumagaye, and K...

a member of homeodomain protein namely tgif2lx has been implicated as a tumor suppressor gene in human malignancy as well as in spermatogenesis. however, to our knowledge, dynamic functional evidence of the tgif2lx has not yet been provided. the aim of the present study was to investigate the human tgif2lx target gene(s) using a cdna-aflp as a differential display method. a pegfp-tgif2lx constr...

Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrator-1 (BIN1), we outline potential advantages and disadvantages of chemical activation of tumor sup...

UNLABELLED The retinoblastoma (Rb) tumor suppressor controls cell cycle, DNA damage, apoptotic, and metabolic pathways. DNA tumor virus oncoproteins reduce Rb function by either inducing Rb degradation or physically disrupting complexes between Rb and its myriad binding proteins. Human cytomegalovirus (HCMV), a betaherpesvirus being investigated for potential roles in human cancers, encodes mul...

The nuclear envelope separates and protects DNA from the cytoplasm. In cancer cells, frequent morphological abnormalities transient rupture of membrane promote damage malignancy. However, instability, acting as a tumor-promotion factor, can be viewed fatal weakness cells. Although exact mechanism is not clear, it known that loss tumor suppressor gene TP53 involved in instability this study, we ...

A substantial part of cutaneous malignant melanomas develops from benign nevi. While the mutational landscape melanoma has been investigated in recent years, molecular events leading to transformation remain less characterized. To explore these processes on a proteomic level, we created cohort (N=166) and identified with nevi remnant same specimen (N=14). We applied combination laser microdisse...

1. Abstract 2. Introduction 3. Human cytomegalovirus 4. Cell cycle 5. Virus effects on the cell cycle 6. Virus effects on cell cycle regulatory proteins 6.1. Rb tumor suppressor family 6.2. p53 tumor suppressor family 6.3. Oncogenes 6.4. Cyclins and cyclin regulators 6.4.1. Cyclin-dependent kinase inhibitors 6.4.2. Cyclins 6.4.3. Cyclin-dependent kinases 7. Viral proteins that alter cell cycle ...

background and objectives: giant cell tumor of bone (gct) is often regarded as a benign tumor, but its clinical course is unpredictable, has a high rate of recurrence, and even can metastases and transform to a malignant tumor. histological features of the tumor often could not predict its future biologic behavior, so it is just called ''giant cell tumor'' without indicating malignancy or benig...