Diagnosis is the key for treatment plan. Some fundamental tasks for accurate diagnosis include: (1) Anatomic localization of the lesion and its relation to surrounding structures which could be determined by CT and /or MRI brain. (2) Evaluation of the activity of this lesion (hyperactive, normal, or silent) by magnetic resonance spectroscopy (MRS). (3) Determining cell of origin of the lesion t...

Cystic changes of the thymus are rare lesions. In addition to their appearance in non-neoplastic congenital and acquired conditions, they have been seen in association with certain malignancies of the thymus. Our aim is to highlight the possibility of confusing between benign and malignant thymus cysts having different cure approach. We report two thymic cyst cases, one congenital ectopic condi...

Tumoral calcinosis is a rare clinical and histopathologic syndrome characterized by calcium salt deposits in periarticular soft tissue.1,2 Softtissue of juxta-articular upper limb (shoulder and elbow) and hip regions are the most commonly involved; however, spinal3-5 and temporomandibular joint6,7 involvement has also been reported. The extensor aspect of the joint is the usual site of the lesi...

Tumoral calcinosis is a rare disorder that presents with ectopic calcifications deposited at different periarticular soft tissue regions of the body- mostly hips, elbows and shoulders. It results from relative deficiency of, or resistance to, phosphate-regulating hormone - Fibroblast Growth Factor 23 (FGF23), due to gene mutations, causing hyperphosphatemia. We describe this condition in 13 yea...

A 59-year-old man with T-cell prolymphocytic leukemia on alemtuzumab presented with neutropenic fever, intermittent nausea, and multiple ill-defined low attenuation foci in the liver on abdominal computed tomography scan which were suspicious for metastatic disease. Histological examination revealed the diagnosis of adenovirus hepatitis. Patient responded well to cidofovir. Adenovirus hepatitis...

A 46-year-old woman under 6-year haemodialysis was admitted for uncontrollable hip pain. An X-ray film revealed calcified mass around the 'left femur head', which was diagnosed as calcium deposition by percutaneous biopsy. Calcinotic tissues were removed surgically, and the resected specimen revealed tumoral calcinosis caused by low bone turnover. A complete resolution of calcinotic lesions aro...

PURPOSE To evaluate both the efficacy and reliability of the cytologic method in the diagnosis of conjunctival lesions and compare it with the histologic examination. METHODS A prospective study on 31 conjunctival lesions was performed. Samples were obtained with a Kimura spatula. The lesions were, then, surgically removed and sent for histologic examination. The Papanicolaou technique was us...

Progression of oral squamous cell carcinoma (OSCC) has been associated with an escape tumor cells from the host immune surveillance due to increased knowledge its underlying molecular mechanisms and modulation by microenvironment repertoire. In this study, expression HLA class I (HLA-I) antigens components antigen processing machinery (APM) was analyzed in 160 pathologically classified human pa...

1 Theaker JM, Gatter KC, and Puddle J. Epithelial membrane antigen expression by the perineurium of peripheral nerve and in peripheral nerve tumors. Histopathology 1988;13:171-9. 2 Theaker JM, Fletcher CDM. Epithelial membrane antigen expression by the perineurial cell: further studies of peripheral nerve lesions. Histopathology 1989;14:581-92. 3 Perentes E, Nakagawa Y, Ross GW, Stanton C, Rubi...