The article describes the application of a twin-screw granulation process to enhance the dissolution rate of the poorly water soluble drug, ibuprofen (IBU). A quality-by-design (QbD) approach was used to manufacture IBU loaded granules via hot-melt extrusion (HME) processing. For the purpose of the study, a design of experiment (DoE) was implemented to assess the effect of the formulation compo...

Barley flour and barley flour-pomace (tomato, grape) blends were extruded through a co-rotating twin-screw extruder. The aim of the present study was to investigate the effects of die temperature, screw speed, and pomace level on water absorption index (WAI), water solubility index (WSI), degree of starch gelatinization, and in vitro starch digestibility using a response surface methodology. Th...

• Extrusion of okra raised the content soluble dietary fiber and free bound phenolic acids. Epigallocatechin was highly susceptible to thermal degradation during screw extrusion. A small portion quercetin-3-O-glucoside found as after Extruded wheat flour-extruded flour blend resulted in elastic cohesive crumbs. This work investigates partial solubilization cell wall polysaccharides flours chang...

Cereal Chem. 71(6):582-587 Commercial corn starches containing 0-70% amylose were extruded formation of complexes between amylose and lipids. Maximum binding with and without various lipids (myristic, stearic, and behenic acids; monowas observed for myristic acid and 70% amylose starch. No binding was glyceride Dimodan PV; and tristearin) in a single-screw laboratory observed with tristearin. P...

Co-rotating twin screw extruders are extensively used in the polymer compounding industry mainly due to their good mixing capacity. Given its modular construction, this type of machines can easily be adapted to work with different polymeric systems, e.g., polymer blends, nanocomposites or highly filled polymers. Nevertheless, the performance of these machines is strongly dependent on the screw ...

Green banana flour was extruded through a co-rotating twin-screw extruder with constant barrel temperature. The objectives of this study were to determine the effect of extrusion cooking variables (feed moisture, FM, 20% and 50%; screw speed, SS, 200 and 400rpm) and storing of the extruded flours at 4°C for 24h on the physicochemical properties, resistant starch (RS), pasting properties and ant...

Composites based on PLA with the addition of 3, 6 and 10 wt% silica, hydroxyapatite bentonite were obtained by twin-screw extrusion. Maleic anhydride grafted polyethylene was used to enhance interface interactions. The influence fillers Charpy impact strength, Rockwell hardness, tensile properties processing shrinkage investigated. Test samples 3D printing. highest strength hardness for composi...