Twin-to-twin transfusion syndrome (TTTS) and twin anemia polycythemia sequence (TAPS) are complications unique to monochorionic twin pregnancies and their shared circulation. Both are the result of the transfusion imbalance in the intertwin circulation. TTTS is characterized by an amniotic fluid discordance, whereas in TAPS, there is a severe discordance in hemoglobin levels. The article gives ...

Richard P Smith PhD MRCOG Subspecialty trainee Fetal Medicine Unit and University of Bristol Fetal Medicine Research Group, St Michael’s Hospital, Southwell Street, Bristol, BS2 8EG, UK E-mail: [email protected] (corresponding author) Mark L Denbow PhD MRCOG Consultant and Honorary Senior Clinical Lecturer Fetal Medicine Unit and University of Bristol Fetal Medicine Research Group, St Michae...

BACKGROUND Echocardiography has documented acquired pulmonary stenosis and cardiomyopathy in recipient fetuses in twin-twin transfusion syndrome. At autopsy, we also have identified anomalous mitral arcade, a rare valve deformity associated with mitral regurgitation. METHODS AND RESULTS To identify a profile for anomalous mitral arcade, we compared clinicopathological data from 11 sets of aut...

Background—Echocardiography has documented acquired pulmonary stenosis and cardiomyopathy in recipient fetuses in twin-twin transfusion syndrome. At autopsy, we also have identified anomalous mitral arcade, a rare valve deformity associated with mitral regurgitation. Methods and Results—To identify a profile for anomalous mitral arcade, we compared clinicopathological data from 11 sets of autop...

OBJECTIVE To assess the neurodevelopmental functions (cognition, language and motor function) of survivors of twin-twin transfusion syndrome (TTTS). METHOD Observational cross-sectional study of a total of 67 monochorionic diamniotic twins who underwent fetoscopic laser coagulation (FLC) for treatment of TTTS. The study was conducted at the Center for Investigation in Pediatrics (CIPED), Univ...

Twin-to-twin transfusion syndrome (TTTS) is a severe complication of monochorionic (MC) twin pregnancies, characterized by the development of unbalanced chronic blood transfer from one twin, defined as donor twin, to the other, defined as recipient, through placental anastomoses. If left untreated, TTTS is associated with very high perinatal mortality and morbidity rates, due to a combination o...

Twin-twin transfusion syndrome leads to high rates of perinatal morbidity and mortality due to its poorly understood etiology and difficult diagnosing and treatment. Current therapies are suboptimal and have not been tested through randomized controlled trials. Parent counseling at the time of diagnosis includes informing on poor chance of double survival, relatively high chance of long term ne...

OBJECTIVE To review the perinatal outcome of monochorionic twin pregnancies treated by fetoscopic laser coagulation for twin-twin transfusion syndrome. DESIGN Retrospective study. SETTING A university teaching hospital in Hong Kong. PATIENTS Thirty consecutive cases of fetoscopic laser coagulation of placental anastomoses for twin-twin transfusion syndrome performed in a single centre. ...

We examined the prevalence of specific perinatal complications of monochorionic-diamniotic twin pregnancies in cases without any abnormal findings until the second trimester of pregnancy. This was a retrospective cohort study performed at a tertiary perinatal center in Tokyo, Japan. There were 88 cases of uncomplicated monochorionic-diamniotic twin pregnancies at 28 weeks of gestation. In five ...