نتایج جستجو برای: type β
تعداد نتایج: 1494932 فیلتر نتایج به سال:
Following recent interest in the qualitative analysis of some optimal control and shape optimisation problems, we provide this article a detailed study Robin boundary conditions PDE constrained calculus variations. Our main model consists an elliptic form −∆u β = f (x, u β) endowed with ∂ν +β(x)u 0. The variable is function β, which assumed to take values between 0 1 have fixed integral. Two ty...
The early occurrence of β-cell dysfunction has been broadly recognized as a critical determinant of the development and progression of type 2 diabetes. β-cell dysfunction might be induced by insufficient β-cell mass, by a dysfunction of the β-cells, or both. Whether or not β-cell dysfunction constitutes a cause of reduced β-cells or vice-versa currently remains unclear. The results of some stud...
OBJECTIVE Type 2 diabetes is characterized by diminished pancreatic β-cell mass and function. Insulin signaling within the β-cells has been shown to play a critical role in maintaining the essential function of the β-cells. Under basal conditions, enhanced insulin-PI3K signaling via deletion of phosphatase with tensin homology (PTEN), a negative regulator of this pathway, leads to increased β-c...
The functional properties of a protein primarily depend on its three-dimensional (3D) structure. These properties have classically been assigned, visualized and analysed on the basis of protein secondary structures. The β-turn is the third most important secondary structure after helices and β-strands. β-turns have been classified according to the values of the dihedral angles φ and ψ of the ce...
Type 2 diabetic patients are insulin resistant as a result of obesity and a sedentary lifestyle. Nevertheless, it has been known for the past five decades that insulin response to nutrients is markedly diminished in type 2 diabetes. There is now a consensus that impaired glucose regulation cannot develop without insulin deficiency. First-phase insulin response to glucose is lost very early in t...
OBJECTIVE β-Cells that express an imaging reporter have provided powerful tools for studying β-cell development, islet transplantation, and β-cell autoimmunity. To further expedite diabetes research, we generated transgenic C57BL/6 "MIP-TF" mice that have a mouse insulin promoter (MIP) driving the expression of a trifusion (TF) protein of three imaging reporters (luciferase/enhanced green fluor...
objective: β-thalassemia is caused by absence or reduction of β-globin chain synthesis. one of the effective therapeutic methods for this disease can be gene therapy by viral vectors. the capacity of lentiviral vectors is approximately 8 kb, we designed a 6 kb construct containing mini lcr and β-globin gene instead of lcr region. the aim of this study is to make a recombinant lentiviruses conta...
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