Accumulating evidence has indicated that expression levels of YKL-40, a secreted glycoprotein, were elevated in multiple advanced human cancers. Recently, we have identified an angiogenic role of YKL-40 in cancer development. However, blockade of the function of YKL-40, which implicates therapeutic value, has not been explored yet. Our current study sought to establish a monoclonal anti-YKL-40 ...

OBJECTIVE To investigate the role of 188Re in human sodium iodide symporter (hNIS) theranostic gene-mediated human glioma imaging and therapy in model mice. METHODS The human glioma cell line U87 was transfected with recombinant lentivirus encoding the hNIS gene under the control of cytomegalovirus promoter (U87-hNIS). The uptake and efflux of 188Re were determined after incubating the cells ...

Glioblastoma Multiforme (GBM) is most aggressive type of brain tumor in adults. 1,4-dimethyl carbazoles exhibits significant anticancer activities literature. In this research article, we synthesized a series novel 1,4-dimethyl-9-H-carbazol-3-yl)methanamine and its derivatives (13-24) evaluated their vitro cytotoxicity against human glioma U87 MG cell line using MTT assay for 24 h phase time pe...

U87-derived stem-like cells (U87-SLCs) were cultured using serum-free stem cell media and identified by both biological behaviors and markers. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and paclitaxel (PX), in combination or alone, was used to treat U87-MG human glioma cells (U87 cells) or U87-SLCs. The results showed that TRAIL/PX cannot only synergistically inhibit ...

Temozolomide (TMZ), as the first-line chemotherapeutic agent for treatment of glioblastoma multiforme (GBM), often fails to improve prognosis GBM patients due quick development resistance. The need more effective management is urgent. aim this study evaluate efficacy combined therapy with TMZ and amlexanox, a selective inhibitor IKBKE, GBM. We found that resulted in significant induction cellul...

The substance P (SP)-preferring receptor, neurokinin-1 receptor (NK-1R), has an important role in inflammation, immune regulation, and viral infection. We applied a newly developed real-time reverse transcription (RT)-PCR assay to quantify NK-1R mRNA in human neuronal cell line (NT-2N), a human B-cell line (IM9), monocyte-derived macrophages (MDM), peripheral blood lymphocytes (PBL), and human ...

The ability of interleukin-4 (IL-4) to mediate an antitumor response to human gliomas was studied in vivo in nude mice. To allow the effect of IL-4 to be exerted over a relatively short distance and at an optimal concentration, a transfected tumor cell line expressing a high level of IL-4 was used in mixed tumor transplantation assays. There was a significant inhibition of growth of the U87 hum...

Background: Spironolactone is a conventional drug widely in use for the treatment of heart failure and hypertension patients. On other side recent studies have reported spironolactone can prevent growth resistance cancer stem cells (CSCs), by inhibiting DNA double-strand break (DSB) repair; suggesting its potential application therapy. Objectives: Our study aimed at assessing cytotoxicity human...

The ability of interleukin-4 (IL-4) to mediate an antitumor response to human gliomas was studied in vivo in nude mice. To allow the effect of IL-4 to be exerted over a relatively short distance and at an optimal concen tration, a transfected tumor cell line expressing a high level of IL-4 was used in mixed tumor transplantation assays. There was a significant in hibition of growth of the U87 h...