PURPOSE To evaluate the association of computed tomography (CT) texture features of locally advanced rectal cancer with neoadjuvant chemoradiotherapy (CRT) response and disease-free survival (DFS). METHODS AND FINDINGS The institutional review board approved this retrospective study. 95 patients who received neoadjuvant CRT, followed by surgery, for locally advanced rectal cancer were include...

OBJECTIVE To evaluate the pharmaceutical equivalence of a test formulation (fixed-dose combination of budesonide and formoterol fumarate in a single capsule dispensed in an Aerocaps® inhaler) in relation to a reference formulation (budesonide and formoterol fumarate in two separate capsules dispensed in an Aerolizer® inhaler). METHODS This was an in vitro study in which we performed the ident...

Abstract Helicon plasma sources are known to be efficient generators of high-density plasma for materials processing applications. By using multiple sources, arbitrarily large substrates can in principle be covered uniformly with dense plasma. To test this idea, a seven-tube helicon source was constructed, and the plasma density and uniformity measured. Densities up to 1012 cm−3 over a 40 cm di...

Existing specification-based testing techniques often generate a comprehensive test suite to cover diverse combinations of test-relevant aspects. Such a test suite can be prohibitively expensive to execute exhaustively due to its large size. A pragmatic strategy often adopted in practice, called test-once, is to identify certain particular conditions from the specification and to test each such...