background: in previous studies, the neuroprotective effect of 17&beta-estradiol; in diffuse traumatic brain injury has been shown. this study used ici 182,780, a non-selective estrogen receptor antagonist, to test the hypothesis that the neuroprotective effect of 17&beta-estradiol; in traumatic brain injury is mediated by the estrogen receptors. methods: the ovariectomized rats were divided in...

In previous studies, the neuroprotective effect of progestrone in diffuse traumatic brain injury has been shown. This study used mifepristone (RU-486), a potent progesterone receptor antagonist, to evaluatethe hypothesis that the neuroprotective effect of progesterone in traumatic brain injury is mediated by the progesterone receptors. The ovariectomized rats were divided into 6 groups. Brain i...

We investigated cerebellar electrocortical activity before and after unilateral brain injury in anesthetized rats. Spectral analysis of cerebellar activity was obtained by Fast Fourier Transformation. There was a dominance of delta frequency range, while the wide gamma range presented no more than 5% of the total mean power spectra of cerebellar activity before brain injury. A few minutes after...

a common pathological process that occurred after brain injury is gliosis. gliosis involves the activation of glial cells to proliferate and become hypertrophic to occupy the injured brain areas. in order to form a defense system against the invasion of micro-organisms and cytotoxins into surrounding tissue, glial cells including astrocytes and microglia undergo reactive response to injury. neu...

Ischemic brain injury from stroke is an important cause of disability in infants and children, but current experimental models for the disorder are complex. These preparations require occlusion of small intracerebral vessels or common carotid artery ligation combined with exposure to reduced levels of oxygen. Unilateral carotid artery ligation alone was sufficient to cause brain injury in more ...

In immature rodent brain, unilateral intrastriatal injections of selected excitatory amino acid (EAA) receptor agonists, such as N-methyl-D-aspartate (NMDA), produce prominent ipsilateral forebrain lesions. In Postnatal Day (PND) 7 rats that receive a right intrastriatal injection of NMDA (25 nmol) and are sacrificed 5 days later, there is a considerable and consistent reduction in the weight o...

conceptually traumatic brain injury (tbi) can be classified from a mechanistic perspective as: 1) closed, 2) penetrating, 3) blast, and 4) crush injuries. thus, tbi is a heterogeneous disease and each type of brain injury has different characteristic features often necessitating different approaches to management. the first edition of the guidelines for management and prognosis of penetrating b...

brain injury has a multiple pathophysiology for which there is no definite treatment. in this regard, tissue engineering is one of the probable strategies for repair of damaged tissue. but creating a proper model for testing the engineered products faced some difficulties, specially, when we want to evaluate the effects of a product on the volume of injury. the current brain injury methods coul...

traumatic brain injury (tbi) initiates a cascade of numerous pathophysiological events that evolve over time. despite the complexity of tbi, research aimed at therapy development has almost exclusively focused on single therapies, all of which have failed in multicenter clinical trials. a variety of brain insults, including traumatic brain injury, encephalitis, stroke, and status epilepticus (s...

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