These studies examined adrenergic reactivity of mesenteric arteries and veins from deoxycorticosterone acetate-salt (DOCA-salt) hypertensive and sham control mice. We measured constrictions in unpressurized arteries and veins by monitoring vessel diameter using computer-assisted video micros-copy in vitro. Veins were more sensitive than arteries to the constricting effects of norepinephrine (NE...

We present a detailed asymptotic analysis of the point indentation of an unpressurized, spherical elastic shell. Previous analyses of this classic problem have assumed that for sufficiently large indentation depths, such a shell deforms by 'mirror buckling'-a portion of the shell inverts to become a spherical cap with equal but opposite curvature to the undeformed shell. The energy of deformati...

Evidence from light microscopy (principally polarization microscopy) has demonstrated that hydrostatic pressure can reversibly inhibit mitosis by rapidly depolymerizing the spindle fiber microtubules. We have confirmed this finding in ultrastructural studies of mitotic HeLa cells incubated at 37 degrees C and pressurized at 680 atm (10,000 psi). Althouth there are many spindle microtubules in t...

We sought to understand the excitation-contraction coupling process in arterioles. KCl or phenylephrine (PE) was applied via the superfusion solution or by brief pulsatile ejections from a micropipette onto unpressurized arterioles (in vitro) from either the guinea pig small intestine or hamster cheek pouch. With either mode of application, KCl caused depolarizations that were tightly and predi...

Batch reverse osmosis (BRO) systems may enable a significant reduction in energy consumption for desalination and water reuse. BRO systems operate with variable pressure, by applying only slightly more pressure than is needed to overcome the osmotic pressure and produce reverse water flux. This study explains, quantifies, and optimizes the energy-saving performance of realistic batch designs im...

Coronary arterioles of exercise-trained (EX) pigs have enhanced nitric oxide (NO.)-dependent dilation. Evidence suggests that the biological half-life of NO. depends in part on the management of the superoxide anion. The purpose of this study was to test the hypothesis that expression of cytosolic copper/zinc-dependent superoxide dismutase (SOD)-1 is increased in coronary arterioles as a result...

ICCS conductors behave anomalously. Several anomalies have been documented: quenches driven by pulsig fields (referred to as ramp-rate limtations), and energy margins that show a transition between a "well-cooled" and an "ill-cooled" regime (marking a transition between high energy margin at low transport current and low energy margin at higher currents). In this paper, a novel model will be de...

The objective of the present work is to examine the influence of pressure up to 193 MPa at subzero temperature (without freezing of water) on myofibrillar proteins of salmon and cod meat and on the properties of gels obtained from washed mince of these fish. The solubility of proteins from myofibrils of cod and salmon meat suspended in 100 mM KCl solution increased after treating the samples wi...

The microstructural organization and composition of the corneoscleral shell (CSS) determine the biomechanical behavior of the eye, and are important in diseases such as glaucoma and myopia. However, limited techniques can assess these properties globally, non-invasively and quantitatively. In this study, we hypothesized that multi-modal magnetic resonance imaging (MRI) can reveal the effects of...