BACKGROUND Because of the poor sensitivity of urinary cytological findings for the diagnosis of especially low grade urinary bladder carcinoma, new molecular diagnostic methods have been proposed. We decided to verify the ImmunoCyt/uCyt+ (UCyt+) test and cytology combination and cytokeratin 20 (CK20) and cytology combination in urine as possible diagnostic and monitoring tool for bladder cancer...

PURPOSE HER-2/neu overexpression is documented in some bladder cancers. To our knowledge, there are no current studies evaluating urine HER-2/neu levels. Therefore, we examined the clinical significance of serum and urine HER-2/neu protein in bladder cancer. MATERIALS AND METHODS Urothelial bladder carcinoma patients (n=38, including 31 men and 7 women) and healthy controls (n=25, including 2...

Microscopic hematuria, a common finding on routine urinalysis of adults, is clinically significant when three to five red blood cells per high-power field are visible. Etiologies of microscopic hematuria range from incidental causes to life-threatening urinary tract neoplasm. The lack of evidence-based imaging guidelines can complicate the family physician's decision about the best way to proce...

Urinary cytology has a well-established role in the detection and monitoring of urothelial carcinoma. The main strength of cytology is the high specificity for high-grade urothelial carcinoma and carcinoma in situ, but it has a low sensitivity for low-grade, non-invasive tumors. There are several other limitations of cytology. Cytology of the upper urinary tract and after intravesical therapy w...

Introduction: Bladder melanosis is an extremely rare condition first reported in 1986 and refers to abnormal deposits of melanin in the urothelial bladder cells. Typically, it is considered a benign condition, but it has also been described associated with urothelial carcinoma and melanoma. Its diagnosis may be difficult for most urologists because of its rarity. Case Report: We present the cas...

Background: The Paris System for Reporting Urinary Cytology (TPS) is considered the gold standard when it comes to diagnostic classifications of urine specimens. Its second edition brought some important changes, including abolition category “low-grade urothelial neoplasm (LGUN)”, acknowledging inability cytology reliably discern low-grade lesions. Methods: In this retrospective study, we asses...

Abstract Background To evaluate the clinical effectiveness of a novel CellDetect staining technique, compared with fluorescent in situ hybridization (FISH), and urine cytology, diagnosis urothelial carcinoma (UC). Methods A total 264 patients suspicious UC were enrolled this study. All tissue specimens collected by biopsy or surgery. Urine specimen was obtained for examinations prior to surgica...