The inhibition of P-glucuronidase by mamResearch Unit, Aberdeen Royal Infirmary, to whom the malian urine has been noted by a number of author is indebted. Fresh samples of cat urine were workers. This complicates assay of the enzyme in supplied by Dr A. J. Carr, Pathology Department, Aberurine, and the use of added *-e to deen University; 24 hr. urines of rat and guinea pig, and urine, and the...

It was a chance discovery that ambroxol parenteral administration led to urinary bladder stone formation in rats. This study was undertaken to examine the serum uric acid levels and urine pH in rats after ambroxol parenteral treatment. Ambroxol influence on the uric acid level was measured in 5 rats (Rattus sp.) treated with 60 mg/kg (dissolved in injection water, sc, daily) during 2 weeks. Amb...

We evaluated the crystallization of calcium oxalate (CaOx) in undiluted urine, collected 3 hours after intake of a test meal by healthy males. In two experiments in vitro, either the total citrate concentration was increased (urine A) or the pH was elevated (urine B). In addition, in three clinical trials, the bioequivalence of orally taken potassium citrate (PC) and potassium-sodium citrate (P...

We report the effect of sample matrix and pH on quantification of porphyrins by HPLC with fluorimetric detection. For aqueous solutions of pH less than 2.5, HPLC peak heights of the porphyrins increased with decreasing pH, reaching a plateau at pH less than 1.0. This loss of porphyrins from solutions with pH greater than 1.0 appeared to be due to a combination of microprecipitation and aggregat...

Aim: Diabetes Mellitus is a heterogeneous group of diseases, characterized by a state of chronic hyperglycemia. Diabetes Mellitus has a number of long-term effects on the genitourinary system predisposing to Urinary Tract Infections and change in pH. This study focuses on the Urine pH analysis of Diabetic patients and its correlation with urine culture and duration of diabetes to assess if devi...

The pharmacodynamics of finafloxacin, ciprofloxacin, and levofloxacin against extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae isolates were compared. Since quinolones lose activity in acidic media, and particularly in urine, their activities were tested in parallel under conventional conditions and in acidic artificial urine. For this purpose, TEM- and SHV-type ESBL-producing ...