conclusions udca decreased the pruritus score, tba, and alt levels more effectively than same, reducing the rate of preterm delivery for icp. evidence acquisition a meta-analysis of all randomized controlled trials (rcts) comparing udca, same, and combination therapy was performed. we carried out a literature search using pubmed, embase, the cochrane register of controlled trials, and the scien...

BACKGROUND/AIMS Despite a proposed role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis, antioxidant approaches have not been investigated sufficiently in the therapy of nonalcoholic steatohepatitis. Our aim was to determine whether vitamin E plus C therapy is effective in normalization of liver enzymes compared to ursodeoxycholic acid treatment in patients with fatty li...

OBJECTIVE To compare the efficacy of S-adenosyl-l-methionine and ursodeoxycholic acid in improving serum biochemical abnormalities in gestational cholestasis. DESIGN Randomised clinical trial. SETTING University hospital. POPULATION All women at <36 weeks of gestation with severe gestational cholestasis during June 1996 to December 2001. METHODS Enrolled women were randomly assigned ora...

BACKGROUND Amyloidosis represents a group of different diseases characterized by extracellular accumulation of pathologic fibrillar proteins in various tissues and organs. Severe amyloid deposition in the liver parenchyma has extrahepatic involvement predominantly in the kidney or heart. We evaluated the effect of ursodeoxycholic acid, in four patients with severe hepatic amyloidosis of differe...