Epigenetic mechanisms determine the access of regulatory factors to DNA during events such as transcription and the DNA damage response. However, the global response of histone modifications and chromatin accessibility to UV exposure remains poorly understood. Here, we report that UV exposure results in a genome-wide reduction in chromatin accessibility, while the distribution of the active reg...

The solar UV exposure to the eyes of humans is due to the direct and diffuse components of solar radiation. The direct ocular UV exposures to the eyes are reduced due to the natural aversion of the majority of people from looking directly at the sun. The diffuse UV is incident from all directions and as a result, it is more difficult to minimise the ocular exposure to this component of the sola...

Outdoor workers who occupationally spend large periods of time exposed to ultraviolet irradiance are at increased risk of developing certain types of non-melanoma skin cancer in addition to being prone to erythema and eye damage. UV exposure to workers is affected by a number of factors including geographic location, season, individual biological factors and the local surroundings. Urban enviro...

PURPOSE Ultraviolet (UV) irradiation exposure represents a significant environmental and occupational hazard that can cause acute and chronic inflammatory changes in the exposed cornea. Acute exposure to solar UV irradiation or to UV irradiation from such artificial sources as tanning lamps can result in severe pain and inflammation in the cornea. Chronic exposure to solar UV irradiation is ass...

This paper presents a method for the evaluation of the distribution of the facial erythemal UV exposure and the erythemal UV exposure per unit area of the face using only eight dosimeters located on the vertex of the head, forehead, nose, chin, left and right ears and left and right cheeks. An overall picture of the parts of the face receiving high UV exposures is provided. The distribution of ...

BACKGROUND In general, measurements of solar ultraviolet (UV) radiation are related to horizontal surfaces. While the humans walking and standing outdoors expose to the natural solar UV radiation, their eyes, cheeks, extremities, trunks, or many other anatomical sites are close to vertical plane and random orient to different directions. In this study, we characterized the diurnal variations in...

Ultraviolet (UV) light alters cutaneous structure and function. Prior work has shown loss of dermal hyaluronan after UV-irradiation of human skin, yet UV exposure increases total glycosaminoglycan (GAG) content in mouse models. To more fully describe UV-induced alterations to cutaneous GAG content, we subjected human volunteers to intermediate-term (5 doses/week for 4 weeks) or single-dose UV e...

The interfering effect of ultraviolet (UV) radiation on the natural function of biological processes is wavelength specific and the UV spectrum must be weighted with the action spectrum for the process. The UV spectral irradiance may be measured with calibrated spectroradiometers. Alternatively, the biologically effective UV may be measured with broadband devices. This paper reviews the techniq...

Quantitative estimates of the childhood and adolescent erythemal ultraviolet (UV) exposure received in South East Queensland schools are provided in this paper for age groups 0 to 6, 7 to 12 and 13 to 19 years. For the neck, hand and lower arm, sites of high UV exposure that are generally not covered by clothing, 13 to 19 year olds received the highest exposure of the three age groups, followed...

Our objective was to test the hypothesis of a short-term late-promoting effect of UV exposure on the development of cutaneous melanoma as explanation for the summer peak in melanoma incidence. Therefore, we studied seasonal variation in melanoma incidence in relation to recent UV exposure using direct UV measurements. Data from the Belgian Cancer Registry on invasive cutaneous melanoma diagnose...