Introduction Caspase-1 is a pro-inflammatory enzyme which gets activated by autoprocessing following the assembly of multiprotein complexes called inflammasomes. Mature caspase-1 is responsible for the activation of the proinflammatory cytokines interleukin (IL)-1b and IL-18. Luksch and colleagues reported naturally occurring CASP1 genetic variants in patients suffering from unexplained recurre...

Introduction Several recent studies have reported a link between vitamin D deficiency and certain chronic inflammatory disorders such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and Behçet’s disease.These recent findings have led to greater emphasis on treatment of vitamin D deficiency and vitamin D supplementation in rheumatological diseases. To our knowledge, vitamin D le...

The purpose of this research was to examine the relationship between plantar pressure distribution and balance in adolescent taekwondo athletes. Twenty-three athletes participated study voluntarily. Pedobarographic method used determine force. Flamingo test for static lower quarter Y dynamic were applied. Pearson correlation balance. A moderate significant negative non-dominant leg at forefoot ...

OBJECTIVES Our objectives were to evaluate the contribution of bergamottin to the grapefruit juice-felodipine interaction and to characterize bergamottin disposition. METHODS In this study 250 mL grapefruit juice; 2-, 6-, or 12-mg capsules of bergamottin plus water; or water was administered with 5 mg extended-release felodipine to 11 volunteers in a partially randomized, 5-way crossover stud...

Marrow cells from 36 patients with myelodysplastic syndromes (MDS) (13 refractory anemia [RA], 14 refractory anemia with excess of blasts [RAEB], 9 RAEB in transformation [RAEB-T]) were evaluated for their in vitro proliferative and differentiative responsiveness to recombinant human granulocyte colony-stimulating factor (G-CSF) or granulocyte-monocyte CSF (GM-CSF). GM-CSF exerted a stronger pr...

Reviewer: 1 Comments to the Author This paper have technical weak points.First the background and references are not adequate!The locality characteristics are found not only with characteristics of 2-tier architecture but also with 3-tier etc. Thus locality characteristics are examined not only in a temporal context but also in client temporal context particularly for web based streams... Secon...

Adults ( N = 54, 80.78 ± 6.08 years) who reported falling during the previous 12 months participated in a 12-week wobble board training program with internal focus or external (EF) instructions. Verbal manipulation checks were performed after sessions as self-report of attentional foci used. The percentage which participants using an EF (EF SR ) was subsequently calculated. Mean velocity and me...