BACKGROUND Luteal phase support is mandatory in assisted reproductive technologies (ART) for optimizing outcome, so the luteal phase is supported with either progesterone, addition of estradiol to progesterone, hCG or gonadotropin releasing hormone (GnRH) agonists. Supplementation of luteal phase with progesterone is prescribed for women undergoing routine IVF treatment. OBJECTIVE To compare ...

BACKGROUND Preterm birth is the major cause of neonatal mortality and morbidity. OBJECTIVE The aim of this study was to evaluate the effect of prophylactic vaginal progesterone on decreasing preterm birth rate and neonatal complications in a high-risk population. MATERIALS AND METHODS A randomized, double-blind, placebo-controlled study was performed on 100 high-risk singleton pregnancies. ...

Objectives: To assess and compare the maintenance of tocolysis in preterm labor by using vaginal intramuscular progesterone. Study design: Randomized controlled trial. Settings study duration: Department Obstetrics & Gynecology, Civil Hospital, Bahawalpur between 12th March 2019 11th September Materials Methods: A total 96 women ranging from 18 40 years age presented with threatened labour,...

OBJECTIVE The pharmacokinetics of a 100 mg vaginal progesterone suppository was evaluated on days 1 and 7 and a 200 mg suppository on day 14. All the volunteers were given oral 17 beta-estradiol during the study. STUDY DESIGN Ten postmenopausal women volunteered for this study. Progesterone was given as a vaginal suppository. Peripheral venous samples were obtained at appropriate intervals an...

Aim This study evaluated the efficacy and safety of vaginal progesterone gel that was administered daily for luteal phase support as part of in vitro fertilization/embryo transfer (IVF/ET) cycles in Japanese women. Methods This was a phase III, multicenter, open-label, single-arm trial in Japanese women undergoing IVF/ET, using the Japanese Society of Obstetrics and Gynecology 2009 registry a...

Background: The purpose of this study was to evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate and neonatal complications in a high-risk population. Materials and Methods: A randomized, double-blind, placebo- controlled study included 100 high-risk singleton pregnancies( prior preterm birth,short cervix,uterine malformations and large intramural uterine m...

UNLABELLED SUMMARY QUESTION: Is vaginal progesterone gel equivalent to vaginal micronized progesterone tablets concerning ongoing pregnancy rate and superior concerning patient convenience when used for luteal support after IVF/ICSI? SUMMARY ANSWER Equivalence of treatments in terms of ongoing live intrauterine pregnancy rate has not been demonstrated; the 95% confidence interval (CI) for the...

the aim of this study was to evaluate the effect of replacing progesterone injections by progesterone vaginal inserts on productive and reproductive parameters of lactating cows with reproductive problems after prolonged periods of heat stress. fifteen holstein cows were randomly assigned to one of three treatments: 1) treated with two progesterone vaginal inserts (p4-ins); 2) treated with prog...

objective: to evaluate the impact of luteal phase support with vaginal progesterone on pregnancy rates in the intrauterine insemination (iui) cycles, stimulated with clomiphene citrate and human menopausal gonadotropin (hmg), in sub fertile couples. materials and methods: this prospective, randomized, double blind study was performed in a tertiary infertility center from march 2011 to january 2...

OBJECTIVE To summarize efficacy and safety data on a new progesterone compound which is available for subcutaneous administration as compared to vaginally administered progesterone for luteal phase support in patients undergoing IVF treatment. DESIGN Data from two randomized phase III trials (07EU/Prg06 and 07USA/Prg05) performed according to GCP standards with a total sample size of 1435 per...